Thirteen-week repeated dose toxicity of Siraitia grosvenori extract in Wistar Hannover (GALAS) rats

Jin, Meilan; Muguruma, Masako; Moto, Mitsuyoshi; Okamura, Miwa; Kashida, Yoko; Mitsumori, Kunitoshi

doi:10.1016/j.fct.2006.12.030

Cited by 16 publications

(11 citation statements)

References 8 publications

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“…The site of implantation and adjacent tissue were excised, fixed in 10 % phosphate-buffered formalin, and decalcified in Plank-Rychlo’s solution (MUTO Pure Chemicals Co., Tokyo, Japan) [ 24 ]. They were then fixed in 4 % paraformaldehyde (Wako, Osaka, Japan), embedded in paraffin, cut into 4-µm-thick sections, and stained with hematoxylin-eosin (HE; Sigma, St. Louis, MO).…”

Section: Methodsmentioning

confidence: 99%

Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

Suenaga

Furukawa

Suzuki

et al. 2015

J Mater Sci: Mater Med

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Mesenchymal stem cell (MSC) condensation contributes to membrane ossification by enhancing their osteodifferentiation. We investigated bone regeneration in rats using the human bone marrow-derived MSC-spheroids prepared by rotation culture, without synthetic or exogenous biomaterials. Bilateral calvarial defects (8 mm) were created in nude male rats; the left-sided defects were implanted with MSC-spheroids, β-tricalcium phosphate (β-TCP) granules, or β-TCP granules + MSC-spheroids, while the right-sided defects served as internal controls. Micro-computed tomography and immunohistochemical staining for osteocalcin/osteopontin indicated formation of new, full-thickness bones at the implantation sites, but not at the control sites in the MSC-spheroid group. Raman spectroscopy revealed similarity in the spectral properties of the repaired bone and native calvarial bone. Mechanical performance of the bones in the MSC-implanted group was good (50 and 60 % those of native bones, respectively). All tests showed poor bone regeneration in the β-TCP and β-TCP + MSC-spheroid groups. Thus, significant bone regeneration was achieved with MSC-spheroid implantation into bone defects, justifying further investigation.

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Section: Methodsmentioning

confidence: 99%

Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

Suenaga

Furukawa

Suzuki

et al. 2015

J Mater Sci: Mater Med

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“…Many animal studies have shown a lack of toxicity of monk fruit extracts (e.g. Jin et al, ; Marone, Borzelleca, Merkel, Heimbach, & Kennepohl, ; Matsumoto et al, ), and in recent human studies, Tey, Salleh, and Henry (, ) found that a beverage containing monk fruit had no effect on total daily energy intake, blood glucose, and insulin responses in healthy human males. Other human studies (not peer reviewed, submitted as part of regulatory applications and not cited) have not given rise to safety concerns.…”

Section: Monk Fruitmentioning

confidence: 99%

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Williamson

Liu

Izzo

2020

British J Pharmacology

238

173

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The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarized and a selection of five newer products, which have not been subject to extensive recent review are profiled: astaxanthin, a carotenoid found in red algae, seafood, salmon and trout, as an antioxidant; cannabidiol, a non‐euphoric marijuana ingredient used as mood enhancer and for painful/inflammatory conditions; modified extracts of ginseng used in new indications including dementia and space travel; monk fruit, a non‐sugar high intensity sweetener and nigella seed, a popular food ingredient and Asian medicine, which has experienced an extraordinary rise in sales recently. Linked Articles This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc

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“…The studies in animals have illustrated no detrimental reproductive or developmental effects on mother or offspring, despite of animals being exposed to high levels of mogrosides daily over long periods [Yang et al, 2015;Food Standards Australia New Zealand (FSANZ), 2008]. There is a lack of toxicological analysis of monk fruit extract examined through animal studies, (Jin et al, 2007;Marone et al, 2008;Matsumoto et al, 2009). Tey et al (2017a) and Tey et al (2017b) observed that a beverage containing monk fruit had no effect on total daily energy consumption, glucose and insulin responses in healthy human males.…”

Section: Safety Assessment Of Monk Fruitmentioning

confidence: 99%

Phytochemical composition and pharmacological impact of natural non-calorie sweetener- monk fruit (Siraitia grosvenorii): a review

Suri

Kathuria

Mishra

et al. 2020

NFS

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Purpose The purpose of this paper is to highlight the biological activities of low-calorie natural sweetener, i.e. monk fruit (Siraitia grosvenorii), which are associated with its bioactive constituents. Design/methodology/approach Recent investigations focused on biochemical characterization and nutraceutical potential of monk fruit (traditional Chinese perennial vine) have been critically reviewed. Also, the safety and influence of monk fruit on organoleptic characteristics of prepared food products have been documented. Findings Biochemistry of monk fruit revealed that mogrosides are the principal compounds responsible for the high-intensity sweetness in the monk fruit. The fruit induces several biological activities including anti-oxidative effect, hypoglycemic response, anti-allergic properties, anti-carcinogenic and anti-tissue damage activities. Attributing to great potential as a bio-functional sweetener in food products, monk fruit extract has been approved as Generally Regarded as Safe. Originality/value This paper highlights the biological potential of monk fruit opening the doors to future investigations for its utilization in products of commercial importance including food and pharmaceutical preparations.

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Thirteen-week repeated dose toxicity of Siraitia grosvenori extract in Wistar Hannover (GALAS) rats

Cited by 16 publications

References 8 publications

Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

Bone regeneration in calvarial defects in a rat model by implantation of human bone marrow-derived mesenchymal stromal cell spheroids

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals

Phytochemical composition and pharmacological impact of natural non-calorie sweetener- monk fruit (Siraitia grosvenorii): a review

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