Thirteen years follow-up after radical transsternal thymectomy for myasthenia gravis. Do short-term results predict long-term outcome?1

Roth, Thierry; Ackermann, R.; Stein, Robert; Inderbitzi, Rolf; Rösler, Kai M.; Schmid, Ralph A.

doi:10.1016/s1010-7940(02)00031-3

Cited by 36 publications

(35 citation statements)

References 20 publications

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“…On the other hand, Huang et al [12] reported that the rates of complete remission increase in years but remain stable after the fourth year. Despite the reports of increased rates of remission, Roth et al [22] determined some relapses many years after the operation but found no significant differences between the short-term and long-term outcomes. In the same study, 90% of the patients who were followed up for 13 years, reported satisfaction with their life quality, and 65% returned to their full time jobs, and 61% reported that they were capable of doing sports such as horseback riding, walking, and swimming regularly.…”

Section: Discussionmentioning

confidence: 96%

“…This suggests that the factors causing the disease are not completely eliminated with thymectomy, but the number of causative factors were reduced or their effects were suppressed. Failure to obtain optimal outcomes after thymectomy procedure have been attributed to several factors, such as incomplete thymectomy, irreversible neuromuscular joint damage, presence of the peripheral lymphoid nodules and spleen that can have thymic effects, presence of peripheral T cells with long life, and heterogeneous disease mechanism (different thymic effects on patients) [22].…”

Section: Discussionmentioning

confidence: 99%

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Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis

Dural¹,

Günal²,

Koçer³

et al. 2015

Turk J Clin Lab

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Aim:The efficiency of thymectomy for treating patients with Myasthenia gravis is a controversial issue. Thus, this study aimed to investigate the efficiency of thymectomy in the treatment of myasthenia gravis based on long-term follow-up results. Material and Methods:The first and fifth year clinical outcomes of 27 patients who had undergone median sternotomy and extended thymectomy for myasthenia gravis between January 1995 and January 2004 were compared statistically. Results:No statistically significant differences were found between the postoperative first and fifth year clinical outcomes of the patients. Conclusions:Thymectomy is a reliable method in the treatment of myasthenia gravis with respect to its long-term outcomes. The outcomes obtained at the end of the first and fifth year of thymectomy are not different.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis

Dural¹,

Günal²,

Koçer³

et al. 2015

Turk J Clin Lab

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“…Thymectomy has been shown to be effective in treating TETs with concomitant MG before surgery, with an improvement rate of 73% to 89%, and a complete remission rate ranging from 28% to 52% (8,(15)(16)(17)(18). Studies to date mainly compared the therapeutic effects of surgery with medical treatment (cholinesterase inhibitors and immunosuppressive agents), with favorable results showing higher improvement rates in patients who received thymectomy than medical treatment (16,17).…”

Section: Discussionmentioning

confidence: 99%

“…Studies to date mainly compared the therapeutic effects of surgery with medical treatment (cholinesterase inhibitors and immunosuppressive agents), with favorable results showing higher improvement rates in patients who received thymectomy than medical treatment (16,17). Up till now, no study has ever compared the effect of the extent of thymectomy on the outcome of surgical treatment for MG with concomitant thymomas.…”

Section: Discussionmentioning

confidence: 99%

Thymectomy versus tumor resection for early-stage thymic malignancies: a Chinese Alliance for Research in Thymomas retrospective database analysis

Shen

et al. 2016

J. Thorac. Dis.

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Background: To evaluate the surgical outcomes of tumor resection with or without total thymectomy for thymic epithelial tumors (TETs) using the Chinese Alliance for Research in Thymomas (ChART) retrospective database. Methods: Patients without preoperative therapy, who underwent surgery for early-stage (Masaoka-Koga stage I and II) tumors, were enrolled for the study. They were divided into thymectomy and thymomectomy groups according to the resection extent of the thymus. Demographic and surgical outcomes were compared between the two patients groups.Results: A total of 1,047 patients were enrolled, with 796 cases in the thymectomy group and 251 cases in the thymomectomy group. Improvement rate of myasthenia gravis (MG) was higher after thymectomy than after thymomectomy (91.6% vs. 50.0%, P<0.001). Ten-year overall survival was similar between the two groups (90.9% after thymectomy and 89.4% after thymomectomy, P=0.732). Overall, recurrence rate was 3.1% after thymectomy and 5.4% after thymomectomy, with no significant difference between the two groups (P=0.149). Stratified analysis revealed no significant difference in recurrence rates in MasaokaKoga stage I tumors (3.2% vs. 1.4%, P=0.259). However in patients with Masaoka-Koga stage II tumors, recurrence was significantly less after thymectomy group than after thymomectomy (2.9% vs. 14.5%, P=0.001).

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“…Myastenia Gravisin tedavisi medikal ve cerrahi tercihleri içermek-tedir. Alta yatan otoimmün mekanizmada asetilkolin reseptörlerine yönlenen spesifik antikorların üretilmesi, oluşan komplekslerin etkisiyle fonksiyonel ve sayısal olarak bu reseptörlerin azalması bulunmaktadır (2). Sahip olduğu fonksiyon ve rollerle timusun bu patogenezde ayrılmaz bir yer aldığını düşünülmektedir.…”

Section: Introductionunclassified

Transsternal Thymectomy

Kara¹,

Yıldızeli²

2012

Toraks Cer Bult

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ÖzetMyastenia Gravis nöromusküler geçişin en yaygın görülen primer hastalığıdır . Myastenia Gravisin tedavisi medikal ve cerrahi tercihleri içermektedir. Timektomi cerrahi tedavinin en önemli parçasını oluşturmakta ve sık olarak uygulanmaktadır. Bu bölümde cerrahi tedavi seçeneklerinden olan transsternal genişletilmiş timektomiden bahsedilecektir. Anahtar kelimeler: Myastenia Gravis, timektomi, transsternal Abstract Myasthenia gravis is the most common primary disease of the neuromuscular junction. Treatment of Myasthenia Gravis consists of medical and surgical options. Thymectomy is the most important part of surgical treatment and is frequently applied. In this section, "transsternal extended thymectomy "is mentioned as one of options of surgical treatment.

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Thirteen years follow-up after radical transsternal thymectomy for myasthenia gravis. Do short-term results predict long-term outcome?1

Abstract: Our data confirm that radical, transsternal thymectomy is an effective and safe therapeutic modality for MG. Short-term results seem to deteriorate over time, therefore long-term studies for minimally invasive approaches have to prove equal results before replacing the standard procedure.

Cited by 36 publications

References 20 publications

Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis

Comparison of the postoperative first and fifth year outcomes in patients who had undergone thymectomy for Myastenia Gravis

Thymectomy versus tumor resection for early-stage thymic malignancies: a Chinese Alliance for Research in Thymomas retrospective database analysis

Transsternal Thymectomy

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