Thirty-Month Follow-Up of Coronary Artery Calcification in Hemodialysis Patients: Different Roles for Inflammation and Abnormal Calcium-Phosphorous Metabolism?

Patsalas, Stavros; Eleftheriadis, Theodoros; Spaia, Sofia; Theodoroglou, Hariklia; Antoniadi, Georgia; Liakopoulos, Vassilios; Passadakis, Ploumis; Vayonas, Georgios; Vargemezis, Vassilis

doi:10.1080/08860220701395010

Cited by 11 publications

(5 citation statements)

References 24 publications

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“…Patsalas and colleagues reported a high percentage of hemodialysis patients (13 of 17 (76%)) maintaining zero CAC over 30 months of follow-up. 24 A similar rate of maintenance of zero CAC was reported for a clinical study of 422 patients referred for CAC scanning. 25 A significantly lower frequency for maintaining zero CAC (33%) was reported by Alagoz et al in 75 kidney donors.…”

Section: Discussionsupporting

confidence: 67%

Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study

Hwang

Onuma²,

Massaro

et al. 2018

Circ: Cardiovascular Imaging

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Section: Discussionsupporting

confidence: 67%

Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study

Hwang

Onuma²,

Massaro

et al. 2018

Circ: Cardiovascular Imaging

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“…VC are not passive process, but it is an active process, in which the vascular cells are transformed to osteoblast like cells. Calcium and phosphorous levels in blood and in tissues are the key players of VC seen in patients with chronic kidney disease (Patsalas et al 2007). In the present study, we found electrolyte changes in the form of elevated serum K + , Na + and PO 4 with significant decrease in serum Ca 2+ caused by adenine administration for 4 weeks.…”

Section: Discussionsupporting

confidence: 62%

Effects of nicorandil on vascular and renal dysfunctions in adenine-induced nephropathy: Possible underlying mechanisms

Hussein

El-Dosoky²,

Malek³

et al. 2019

gpb

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Vascular dysfunctions in chronic kidney disease (CKD) include endothelial dysfunctions and vascular calcification (VC). In the present study, we examined the possible protective effect of nicorandil (potassium channel opener) on renal and vascular dysfunctions in a rat model of adenine-induced nephropathy and its underlying mechanisms. Thirty-four male Sprague-Dawley rats were randomly allocated into 3 groups: Control group, Adenine group (animals received high-adenine diet for 4 weeks), and Nicorandil group (animals received adenine for 4 weeks and nicorandil 1 mg/kg per oral for 4 weeks). The results showed significant reduction in the body weight, heart rate (HR), hemoglobin contents, serum Ca 2+ and reduction in the expression of mRNA of endothelial nitric oxide synthase (eNOS) and nuclear factor erythroid related factor 2 (nrf2) genes in aortic tissues with significant increase in arterial blood pressure (ABP), serum creatinine, blood urea nitrogen (BUN), plasma renin activity (PRA), K + and phosphate (PO 4 3-), urinary albumin excretion (UAE) and aortic VC in Adenine group compared to normal group (p < 0.05). On the other hand, coadminsitration of nicorandil caused significant improvement in the studied parameters compared to Adenine group (p < 0.05). We concluded that nicorandil has a potential protective effect against the vascular and renal impairment induced by adenine, which might be due to attenuation of vascular calcifications, activation of Nrf2 and eNOS genes in aortic tissues.

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“…Furthermore, inflammation is associated with a high hepcidin concentration, which increases the ferritin concentration, thereby reducing the free serum iron concentration and TSAT [28]. Patsalas et al reported that the serum concentration of the inflammatory marker CRP is high in HD patients who have a high CACS [29]. In the present study, we have shown weak correlations between serum CRP and Fe, and serum CRP and ferritin, and no significant correlation was found between serum CRP and TSAT.…”

Section: Discussioncontrasting

confidence: 56%

Iron, coronary artery calcification, and mortality in patients undergoing hemodialysis

Mizuiri¹,

Nishizawa²,

Doi

et al. 2021

Renal Failure

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Objective: A high coronary artery calcification score (CACS) may be associated with high mortality in patients undergoing hemodialysis (HD). Recently, effects of iron on vascular smooth muscle cell calcification have been described. We aimed to investigate the relationships between iron, CACS, and mortality in HD patients. Methods: We studied 173 consecutive patients who were undergoing maintenance HD. Laboratory data and Agatston's CACS were obtained at baseline for two groups of patients: those with CACS !400 (n ¼ 109) and those with CACS <400 (n ¼ 64). Logistic regression analyses for CACS !400 and Cox proportional hazard analyses for mortality were conducted. Results: The median (interquartile range) age and duration of dialysis of the participants were 67 (60-75) years and 73 (37-138) months, respectively. Serum iron (Fe) and transferrin saturation (TSAT) levels were significantly lower in participants with CACS !400 than in those with CACS <400, although the serum ferritin concentration did not differ between the groups. TSAT !21% was significantly associated with CACS !400 (odds ratio 0.46, p<0.05). TSAT !17%, Fe !63 mg/ dL, and ferritin !200 ng/mL appear to protect against 5-year all-cause mortality in HD patients, independent of conventional risk factors of all-cause mortality (p < 0.05). Conclusion:We have identified associations between iron, CACS, and mortality in HD patients. Lower TSAT was found to be an independent predictor of CACS !400, and iron deficiency (low TSAT, iron, or ferritin) was a significant predictor of 5-year all-cause mortality in HD patients.

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Thirty-Month Follow-Up of Coronary Artery Calcification in Hemodialysis Patients: Different Roles for Inflammation and Abnormal Calcium-Phosphorous Metabolism?

Cited by 11 publications

References 24 publications

Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study

Maintenance of Ideal Cardiovascular Health and Coronary Artery Calcium Progression in Low-Risk Men and Women in the Framingham Heart Study

Effects of nicorandil on vascular and renal dysfunctions in adenine-induced nephropathy: Possible underlying mechanisms

Iron, coronary artery calcification, and mortality in patients undergoing hemodialysis

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