“…However, there are far fewer studies that address the left arc of the cycle. The left arc represents mechanisms by which advancing disease disrupts neural and endocrine circuits that mediate the stress response, producing neuropsychiatric symptoms such as depression, anxiety, insomnia and malaise (for review, see: Pedersen et al, 2001a ; Silverman et al, 2005 ; Du and Pang, 2015 ; Michael Caudle, 2016 ; Wulsin et al, 2016 ). A clear example of this is pituitary tumors that release excess hormones to cause physiologic and psychologic pathologies secondary to tumor growth (e.g.…”