This is what asthma looks like: Review of new and emerging functional imaging methods and results

Eddy, Rachel L.; Svenningsen, Sarah; Kassay, Andrea; McCormack, David G.; Nair, Parameswaran; Párraga, Grace

doi:10.1080/24745332.2017.1393637

Cited by 2 publications

(1 citation statement)

References 103 publications

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“…In asthma, airway abnormalities are patient specific, heterogeneously distributed and tend to persist and reoccur in the same location over time [ 16 ]. Hence, it is possible that conventional BT may be treating airways that do not contribute to patient symptoms or disease severity.…”

Section: Introductionmentioning

confidence: 99%

Bronchial thermoplasty guided by hyperpolarised gas magnetic resonance imaging in adults with severe asthma: a 1-year pilot randomised trial

et al. 2021

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Patient-specific localisation of ventilation defects using hyperpolarised gas magnetic resonance imaging (MRI) introduces the possibility of regionally targeted bronchial thermoplasty (BT) for the treatment of severe asthma. We aimed to demonstrate that BT guided by MRI to ventilation defects reduces the number of radiofrequency activations while resulting in improved asthma quality-of-life and control scores that are non-inferior to standard BT.In a 1-year, pilot randomised-controlled trial, 14 patients with severe asthma who were clinically eligible to receive BT, underwent hyperpolarised gas MRI to characterise ventilation defects and were randomised to MRI-guided or standard BT. Endpoints were improved Asthma Quality-of-Life Questionnaire (AQLQ) and Asthma Control Questionnaire (ACQ) scores, the proportion of AQLQ and ACQ responders and the number of radiofrequency activations and bronchoscopy sessions.Participants who underwent MRI-guided BT received 53% fewer radiofrequency activations compared to those who had standard BT (p=0.003). At 12-months, the mean improvement from baseline was similar in both groups for AQLQ score (MRI-guided n=5, 1.8 [95% CI, 0.1 to 3.5], p=0.04; standard n=7, 0.7 [95% CI, −0.9 to 2.3], p=0.30) (p=0.25) and ACQ-5 score (MRI-guided n=5, −1.4 [95% CI, −2.6 to −0.2], p=0.03; standard n=7, −0.7 [95% CI, −1.3 to 0.0], p=0.04) (p=0.17). A similar proportion of participants in both groups achieved a clinically relevant improvement in AQLQ (MRI-guided, 80%; standard, 71%) and ACQ-5 scores (MRI-guided, 80%; standard, 57%).Hyperpolarised gas MRI-guided BT reduced the number of radiofrequency activations, and resulted in asthma quality-of-life and control improvements at 12-months that were non-inferior to standard BT.

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Section: Introductionmentioning

confidence: 99%