Thoracic Cardiovascular Complications of Tuberculosis

Restrepo, Carlos S.; Gonzalez, Tomas V.; Brar, Rahat; Ocazionez, Daniel; Velasco, Marta Lucia; Lopez, Rolando A.; Arias, Liliana; Baxi, Ameya; Carrillo, Jorge

doi:10.1097/rct.0000000000001024

Cited by 5 publications

(3 citation statements)

References 82 publications

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“…Consequently, constrictive pericarditis with PC may exhibit a more chronic course than cases without calcification. However, it is crucial to acknowledge that pericardial calcification can be detected as a sequela of constrictive pericarditis, regardless of whether the tuberculosis is chronic or of recent onset [ 12 ]. In such cases, the association between disease progression and calcification may not be apparent, particularly when the predominant etiology within the study population is considered [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of pericardial calcification on early postoperative outcomes after pericardiectomy: a retrospective observational study

Lee,

Joo

et al. 2024

J Cardiothorac Surg

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Background Owing to the lack of understanding of the clinical significance of pericardial calcification during pericardiectomy, whether pericardial calcification should be considered when determining the optimal timing for pericardiectomy is debatable. We aimed to investigate the effect of pericardial calcification on early postoperative outcomes in patients who underwent pericardiectomy for constrictive pericarditis. Methods Altogether, 44 patients who underwent pericardiectomy for constrictive pericarditis were enrolled. After excluding three patients who underwent concurrent surgeries, a total of 41 patients were categorized into two groups based on the presence of pericardial calcification as determined by preoperative computed tomography and pathological examination. Preoperative clinical and imaging characteristics, intraoperative data, and early postoperative outcomes were compared between the two groups. A multivariable analysis was performed to identify the factors associated with postoperative complications. Results The group with and without PC comprised 21 and 20 patients, respectively. No significant differences were observed in 30-day mortality (n = 1 [5%]) in the group with pericardial calcification and no mortality in the group without pericardial calcification (p > 0.999). Other early postoperative outcome variables did not demonstrate any significant differences between the two groups. However, the use of cardiopulmonary bypass was associated with postoperative complications (p < 0.009, odds ratio: 63.5, 95% confidence interval: 5.13–3400). Conclusions Pericardial calcification did not significantly affect the postoperative outcomes after pericardiectomy. Further comprehensive studies, including those with larger sample sizes and longitudinal designs, are necessary to determine whether pericardial calcification can significantly influence the timing of surgical intervention.

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Section: Discussionmentioning

confidence: 99%

Impact of pericardial calcification on early postoperative outcomes after pericardiectomy: a retrospective observational study

Lee,

Joo

et al. 2024

J Cardiothorac Surg

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“…Diagnosis of TM remains challenging because consensus-based diagnostic criteria are lacking ( 18 , 22 ). Histopathological evaluation remains the standard method for determining the presence of TB lesions.…”

Section: Discussionmentioning

confidence: 99%

Case report: Sudden unexpected death due to tuberculous myocarditis involving sinus node at autopsy

Zhang

Huang

2023

Front. Cardiovasc. Med.

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Tuberculous myocarditis (TM) is an extremely rare manifestation of Mycobacterium tuberculosis (TB) infection. Although TM is a critical cause of sudden cardiac death, only a few cases have been reported. We report the case of an older patient with pulmonary TB with a history of fever, chest tightness, paroxysmal palpitations, and electrocardiographic evidence of sinus node conduction abnormalities on admission. Although emergency physicians observed these unusual clinical manifestations, no timely differential diagnosis was made nor interventions were performed. A definitive diagnosis of TM and histopathological findings compatible with sinus node involvement were made based on autopsy outcomes. Herein, we describe the clinical presentation and pathological features of a rare form of Mycobacterium TB. In addition, we provide an overview of issues related to the diagnosis of myocardial TB.

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“…Other rare cardiovascular complications have been mentioned in the literature, such as Rasmussen aneurysms, affectation of bronchial and non-bronchial systemic arteries, mediastinal fibrosis, and annular sub-valvular ventricular aneurysms [68].…”

Section: Tuberculosis and Other Complicationsmentioning

confidence: 99%

Tuberculosis and Cardiovascular Complications: An Overview

Adefuye¹,

Manjunatha²,

Ganduri³

et al. 2022

Cureus

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Tuberculosis (TB) is a dominant cause of mortality from a single infectious disease agent. It is a global health issue that has been tagged as a public health emergency for decades. The disease process, which is caused by Mycobacterium tuberculosis (MTB), affects the respiratory system as well as many other organ systems in the body, such as the lymphatic system, central nervous system (CNS), gastrointestinal system, and cardiovascular system (CVS). Generally, cardiovascular diseases are the leading cause of death worldwide, with most of the mortality in low and middle-income countries. Also, the high mortality rate of TB is skewed to these regions, making the mortality of TB with CVS involvement exceptionally high.The multisystemic involvement of TB impacts the cardiovascular system in various forms. While pericarditis caused by TB is quite common, other complications like myocarditis, coronary artery disease, and aortitis are rarer, necessitating a high index of suspicion and holistic management. This article reviews the pathophysiology of cardiovascular complications in TB, highlighting mechanisms of occurrence, common complications, management protocols, and prognostic factors. Our review highlights some of the gaps in understanding cardiovascular complications in TB, necessitating further research to investigate causal mechanisms and treatment.

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Thoracic Cardiovascular Complications of Tuberculosis

Cited by 5 publications

References 82 publications

Impact of pericardial calcification on early postoperative outcomes after pericardiectomy: a retrospective observational study

Impact of pericardial calcification on early postoperative outcomes after pericardiectomy: a retrospective observational study

Case report: Sudden unexpected death due to tuberculous myocarditis involving sinus node at autopsy

Tuberculosis and Cardiovascular Complications: An Overview

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