Thoracic cavity remodeling and pulmonary function change after chest wall resection

Abstract

Background Chest wall resection (CWR) is an essential procedure for treating malignancies and infectious conditions of the chest wall. However, there are few studies on the pulmonary function and changes in thoracic cavity volume (TCV) related to CWR. This study aims to investigate the effects of CWR on long-term changes in TCV and pulmonary function. Methods Data of patients who underwent CWR between 2001 and 2021 were retrospectively reviewed. Patients who underwent single rib or lung resection rather than wedge resection were excluded. TCV (liter) was defined as the sum of the right and left TCVs (RCV and LCV) and was measured using computed tomography image reconstruction software. Changes in pulmonary function and TCV 1 year postoperatively were analyzed. Results A total of 45 patients were included. The number of resected ribs was 2 in 16 (35.6%) and ≥3 in 29 (64.4%) patients. Thirty patients underwent reconstruction. Long-term post-CWR decreased in forced vital capacity (FVC) (−7.9%, P=0.004) and forced expiratory volume in 1 second (FEV 1 ) (−7.0%, P=0.002) were significant. There was no significant decrease in FEV 1 /FVC ratio (−3.0%, P=0.06), diffusing capacity of the lung for carbon monoxide (DLCO) (−5.9%, P=0.18) and TCV (−3.1%, P=0.10). There was no correlation between changes in TCV and decreases in FVC (r=0.12, P=0.56) or FEV 1 (r=0.15, P=0.45). After right-side CWR (n=27), RCV (−7.8%, P=0.01) decreased significantly, whereas LCV (+2.1%, P=0.58) did not. The left-side CWR exhibited an identical pattern. (LCV: −8.5%, P=0.004; RCV: +1.3%, P=0.85). In the ≥3 rib-resection group, FVC (−9.5%, P=0.02), FEV 1 (−7.9%, P=0.02) and TCV (−6.4%, P=0.04) decreased significantly. No significant changes were noted in the 2 rib-resection group. There were no significant differences in the changes in pulmonary function nor TCV between the reconstruction and no-reconstruction groups. Conclusions The long-term decrease in pulmonary function after CWR was significant, especially after ≥3-rib resection.