Thoracic Endometriosis Unmasked by Ovarian Hyperstimulation for in vitro Fertilization

Halvorson, Stephanie; Ricker, Mari A.; Barker, Alan F.; Patton, Phillip E.; Harrison, Rebecca; Hunter, Alan J.

doi:10.1007/s11606-011-1959-3

Cited by 11 publications

(6 citation statements)

References 21 publications

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“…D'Hooghe et al, 2006;Coccia et al, 2010;van der Houwen et al, 2014b Deep invasive endometriosis may progress with ovarian stimulation. Very low Renier et al, 1995;Anaf et al, 2010;Halvorson et al, 2012 The conclusions are presented in decreasing order of reliability.…”

Section: Discussionmentioning

confidence: 99%

“…Details of the degree of responsiveness to ovarian stimulation and the specific forms of endometriosis detected at surgery were not reported. Finally, Halvorson et al (2012) described a case of symptomatic thoracic endometriosis diagnosed immediately after IVF. The woman developed symptoms suggestive of ovarian hyperstimulation syndrome (OHSS) 3 days after the retrieval of 30 oocytes.…”

Section: Case Reportsmentioning

confidence: 99%

“…She then recovered but, after achieving pregnancy with frozen embryos, she was diagnosed with congenital diaphragmatic agenesis and underwent surgical repair that revealed the local presence of endometriosis. On this basis, the authors reinterpreted the events that occurred at the time of IVF and opted for a final diagnosis of thoracic endometriosis syndrome rather than OHSS (Halvorson et al, 2012).…”

Section: Case Reportsmentioning

confidence: 99%

See 2 more Smart Citations

Ovarian stimulation and endometriosis progression or recurrence: a systematic review

Somigliana

Viganò

Benaglia

et al. 2019

Reproductive BioMedicine Online

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show abstract

Section: Discussionmentioning

confidence: 99%

Section: Case Reportsmentioning

confidence: 99%

Section: Case Reportsmentioning

confidence: 99%

See 1 more Smart Citation

Ovarian stimulation and endometriosis progression or recurrence: a systematic review

Somigliana

Viganò

Benaglia

et al. 2019

Reproductive BioMedicine Online

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show abstract

“…A chest computed tomography showed bilateral pleural effusion and a subsequent thoracentesis revealed hemorrhagic pleural fluid. This case had 30 oocytes retrieved and developed OHSS with hemorrhagic pleural effusion as described above [ 14 ]. The second case developed pneumothorax after in vitro fertilization and embryo transfer.…”

Section: Discussionmentioning

confidence: 99%

A Case with Severe Endometriosis, Ovarian Hyperstimulation Syndrome, and Isolated Unilateral Pleural Effusion after IVF

Sopa

Larsen

Andersen

2017

Case Reports in Obstetrics and Gynecology

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We present a very rare case of right-sided isolated pleural effusion in a patient with severe endometriosis who, in relation to in vitro fertilization (IVF), developed ovarian hyperstimulation syndrome (OHSS). Earlier laparotomy showed grade IV endometriosis including endometriotic implants of the diaphragm. The patient had no known risk factors for OHSS and only a moderate number of oocytes aspirated. She received, however, repeated hCG injections for luteal support. The patient did not achieve pregnancy but was hospitalized due to pain in the right side of the chest and dyspnoea. A chest computed tomography (CT) showed a pleural effusion on the right side. Total of 1000 ml of pleural fluid was drained after a single thoracentesis. After three days, the symptoms and fluid production ceased. Ascites is a common finding in OHSS, but pleural effusions are rare. Further, isolated pleural effusions have not previously been described in a patient with endometriosis. We suggest that the repeated hCG injections induced effusions from the endometriotic lesions at the diaphragm and as a consequence this patient developed isolated hydrothorax.

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“…Several independent large case series failed to highlight major detrimental effects [[5], [6], [7], [8], [9], [10]]. On the other hand, these reassuring data contrast with some case reports of severe complications [[11], [12], [13], [14], [15]]. The main characteristics of these cases are summarized in Table 1.…”

Section: Introductionmentioning

confidence: 98%

The impact of IVF on deep invasive endometriosis

Berlanda

Benaglia

Bottelli

et al. 2019

European Journal of Obstetrics & Gynecology and Reproductiv

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Objective Ovarian hyper-stimulation during IVF is associated with a significant raise in serum estrogens and one may expect detrimental effects on estrogen-dependent diseases such as endometriosis. However, available evidence from large case series of affected women performing IVF is generally reassuring with the possible exception of women carrying deep invasive lesions. On this basis we deemed important investigating more in depth whether women with deep invasive endometriosis could be a subgroup at higher risk of recurrence or disease progression during IVF. Study design Women with endometriosis who underwent IVF and who had a second evaluation after 3–6 months from a failed cycle were retrospectively reviewed. The main inclusion criteria were the presence of deep invasive endometriosis and/or a history of surgery for this form of the disease. The primary aim of the study was to determine the frequency of endometriosis-related complications in the interval between the two evaluations. Secondary aims were pain symptoms and lesion size modifications. Results Eighty-four women were ultimately selected: baseline ultrasound documented deep invasive lesions in 60 of them. One case of possible endometriosis-related complication was recorded, corresponding to a rate of 1.2% (95%: 0.05%–5.5%) for the whole cohort and 1.7% (95%CI: 0.08–7.6%) for the subgroup of women with ultrasound detected lesions. This rate appears similar to the reported frequency of endometriosis progression in women not receiving IVF. No significant modifications in pain symptoms or lesions size occurred. Conclusions Women with deep invasive endometriosis who underwent IVF do not seem to be exposed to a substantially increased risk of recurrence/disease progression. Larger evidence from independent groups is however required for a definitive conclusion.

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Thoracic Endometriosis Unmasked by Ovarian Hyperstimulation for in vitro Fertilization

Cited by 11 publications

References 21 publications

Ovarian stimulation and endometriosis progression or recurrence: a systematic review

Ovarian stimulation and endometriosis progression or recurrence: a systematic review

A Case with Severe Endometriosis, Ovarian Hyperstimulation Syndrome, and Isolated Unilateral Pleural Effusion after IVF

The impact of IVF on deep invasive endometriosis

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