Thoracic Manifestations of Connective Tissue Diseases

Kusmirek, Joanna; Kanne, Jeffrey P.

doi:10.1053/j.sult.2018.12.003

Cited by 12 publications

(9 citation statements)

References 142 publications

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“…However, no significant differences were observed in CTD-ILD and non-CTD-ILD. Lung involvement is an unfavorable prognosis factor in CTD [31]. Although systemic treatment is always needed in CTD, predicting the response to treatment in CTD-ILD, especially the lung lesions, is difficult.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of fractional exhaled nitric oxide in interstitial lung disease

Lin¹,

Guo²,

Song³

et al. 2020

Preprint

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Background No established biomarkers are available to guide the treatment of chronic interstitial lung diseases (ILDs). Nitric oxide reflects the inflammation in the airway, and fractional exhaled nitric oxide (FeNO) is a non-invasive and reproducible biomarker in lung-disease diagnosis and treatment. Whether FeNO can help manage ILDs remains uncertain. This study aimed to determine the role of FeNO in ILDs and the association between FeNO and ILD subtype. Methods 53 patients with ILDs were retrospectively recruited. Patient characteristics, FeNO values, blood tests for inflammatory markers, and pulmonary function test data were obtained. ResultsThis group of patients with ILDs had decreased vital capacity(VC)and total lung capacity(TLC) of 71.75 ± 17.58% and 75.27 ± 14.07%, respectively. The diffusion capacity of the lung for carbon monoxide(DLCO) also declined, with an average level of 38.15 ± 11.10%. The average FeNO value was 20.34 ± 9.97 ppb. According to the characteristics of chest computed tomography, patients were divided into usual interstitial pneumonia (UIP)-ILD (n = 24) and non-UIP-ILD (n = 29). The FeNO value in the UIP-ILD group was 12.58 ± 3.63 ppb. This value was significantly lower than that of the non-UIP-ILD group (26.62 ± 8.61 ppb, P<0.0001).According to the etiology, all patients with ILDs were divided into connective tissue diseases associated with interstitial lung disease (CTD-ILD) (n = 30) and non-CTD-ILD (n = 23). There were more female patients in CTD-ILD group compared to non-CTD ILD group and patients in CTD-ILD group were younger. With regard to the FeNO, PFT values, and systemic inﬂammatory markers, no signiﬁcant differences were observed between groups. In the overall ILD population, FeNO level correlated with blood eosinophil (r = 0.3066, P=0.0333), but no statistical significant correlations were observed between the FeNO and blood eosinophil percentage, IgE or systemic inﬂammatory markers. The FeNO cut-off value of 18.5 ppb showed a sensibility of 83.3% and a speciﬁcity of 95.8% in discriminating non-UIP-ILDs from UIP ILDs. Conclusions Our study suggested the importance of FeNO test in patients with ILDs. High FeNO levels may indicate the need of systemic treatment, and FeNO can be a helpful biomarker for ILD management.

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Section: Discussionmentioning

confidence: 99%

Evaluation of fractional exhaled nitric oxide in interstitial lung disease

Lin¹,

Guo²,

Song³

et al. 2020

Preprint

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“…(10) As principais características tomográficas são bronquiectasia e/ou bronquiolectasia de tração basilares e periféricas, com ou sem faveolamento, e opacidades em vidro fosco mínimas ou ausentes. (2,11) A apresentação por imagem da AR-PIU e da FPI pode ser idêntica. Chung et al (12) descreveram três características que favorecem a presença de doenças reumáticas autoimunes como etiologia da PIU em oposição à FPI: faveolamento exuberante; sinal da borda reta, caracterizado como isolamento de fibrose nas zonas inferiores com demarcação nítida entre pulmão fibrótico e normal no plano craniocaudal e sem extensão substancial de fibrose ao longo das margens laterais na imagem coronal; e acometimento do lobo superior anterior (Figura 1).…”

Section: Pneumonia Intersticial Usual Associada à Arunclassified

“…A apresentação tomográfica da PINE é tipicamente homogênea e simétrica, e a bronquiectasia de tração é muitas vezes relativamente central em comparação com a PIU. (2,10,11) O terceiro padrão mais comum de DPI na AR é a PO, que tende a ser mais agressiva e a determinar mais sintomas do que a PO criptogênica. (7,14) As características tomográficas da PO variam e geralmente incluem consolidações periféricas e peribroncovasculares, opacidades em vidro fosco e, menos frequentemente, nódulos (Figura 3).…”

Section: Pneumonia Intersticial Não Específica E Outros Padrões De Dpiunclassified

“…Essas anormalidades são muitas vezes passageiras ou migratórias. (10,11) A pneumonia intersticial linfocítica (PIL) é uma DPI linfoproliferativa benigna que pode ocorrer em pacientes com AR, mas ocorre mais comumente em associação com a síndrome de Sjögren (SS). Como a SS secundária é a manifestação extra-articular mais comum na AR, afetando aproximadamente 35% dos pacientes, os casos de PIL na AR podem estar associados à SS.…”

Section: Pneumonia Intersticial Não Específica E Outros Padrões De Dpiunclassified

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Tomographic pleuropulmonary manifestations in rheumatoid arthritis: a pictorial essay

et al. 2023

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Rheumatoid arthritis (RA) is an autoimmune inflammatory and heterogeneous disease that affects several systems, especially the joints. Among the extra-articular manifestations of RA, pleuropulmonary involvement occurs frequently, with different presentations, potentially in all anatomic thoracic compartments, and may determine high morbidity and mortality. The most common pleuropulmonary manifestations in patients with RA include interstitial lung disease (ILD), pleural disease, pulmonary arterial hypertension, rheumatoid lung nodules, airway disease (bronchiectasis and bronchiolitis), and lymphadenopathy. Pulmonary hypertension and ILD are the manifestations with the greatest negative impact in prognosis. HRCT of the chest is essential in the evaluation of patients with RA with respiratory symptoms, especially those with higher risk factors for ILD, such as male gender, smoking, older age, high levels of rheumatoid factor, or positive anti-cyclic citrullinated peptide antibody results. Additionally, other etiologies that may determine tomographic pleuropulmonary manifestations in patients with RA are infections, neoplasms, and drug-induced lung disease. In these scenarios, clinical presentation is heterogeneous, varying from being asymptomatic to having progressive respiratory failure. Knowledge on the potential etiologies causing tomographic pleuropulmonary manifestations in patients with RA coupled with proper clinical reasoning is crucial to diagnose and treat these patients.

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“…Studies on the importance of CT and its possible alterations have been carried out in relation to several diseases in vertebrates (Kusmirek & Kanne, 2019). There are a few works that mention alterations in CT in insects (Ashhurst, 1982;Pedersen, 1991;Zara & Caetano, 2002), although no work mentions morphological and morphometric alterations due to juvenile hormone (JH) analog insecticide contact, like pyriproxyfen.…”

Section: Introductionmentioning

confidence: 99%

Sublethal Concentration of Pyriproxyfen Reduces Testicular Connective Tissue Thickness in Euschistus heros Fabr. (Hemiptera: Pentatomidae)

Matsumoto¹,

Cremonez²,

Roggia³

et al. 2021

JAS

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The aim of this study was to determine the effect of the insecticide pyriproxyfen (Tiger™ 100 CE), juvenile hormone analogue, when applied in a sublethal LC30 concentration (0.668 mL a. i. L-1), on the morphological and morphometric parameters of external and internal connective tissue (CT) of the Neotropical-brown stink bug Euschistus heros testicles. The insecticide was applied on nymphs from the 4th instar using a Potter tower with a working pressure of 82.73 kPa (12 lb pol-²) and 1 mL of the emulsion per replicate. A completely randomized experimental design was used, consisting of two treatments (control and pyriproxyfen-treated), five repetitions, and 10 adults of E. heros per experimental unit. The insects were maintained under controlled conditions until the emergence of adults. After 48 h of emergence of adults, the testicles were collected, fixed, and processed for morphological and morphometric analyses. A change was observed in the collagen fibers of the CT of treated insects when compared with those of controls. It was also observed that both types of CT (dense irregular and loose) over the internal tunic of the treated insect were thinner than those in control insects. The analysis showed that pyriproxyfen significantly reduced the external and internal CT width and the conformation of its fibers in all the observed regions when compared with the controls; this may affect the production of the three different types of sperm present in this species.

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Thoracic Manifestations of Connective Tissue Diseases

Cited by 12 publications

References 142 publications

Evaluation of fractional exhaled nitric oxide in interstitial lung disease

Evaluation of fractional exhaled nitric oxide in interstitial lung disease

Tomographic pleuropulmonary manifestations in rheumatoid arthritis: a pictorial essay

Sublethal Concentration of Pyriproxyfen Reduces Testicular Connective Tissue Thickness in Euschistus heros Fabr. (Hemiptera: Pentatomidae)

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