Thoracic neuroblastoma

Ware, George William

doi:10.1016/s0022-3476(56)80016-4

Cited by 11 publications

(4 citation statements)

References 33 publications

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“…In modern practice sweating would be regarded as an indication for estimation of catecholamine levels in the blood and urine and functional activity would be confirmed by this method. Persistent pyrexia was recorded by Ware (1956) in 13 of the 80 cases recorded and in some of these activity may have existed, though sweating was not specifically described. It is difficult to imagine such gross symptoms arising from the presence of the tumour, as in our case, continuing till death and not being remarked upon if this functional activity once established does, in fact, continue to the time of the patient's death.…”

Section: Discussionmentioning

confidence: 93%

“…A likely reason for Mason's et al (1957) case being the first reported is that the biological assay of catecholamines is itself a recent introduction and that previously no method was available to detect functional activity had this been suspected. However, it does seem odd that in the 44 personal cases of neuroblastoma described by Koop, Kiesewetter and Horn (1955), the 80 cases reviewed by Ware (1956) Schweisguth, Mathey, Renault and Binet (1959), neither elevation of the blood pressure nor excessive sweating is recorded in a single instance. If the condition is so uncommon it seems difficult to explain the reporting of a number of cases, including the present one, since 1957.…”

Section: Discussionmentioning

confidence: 94%

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Functionally Active Intrathoracic Neuroblastoma

Ra¹,

Tp²,

Morris³

et al. 1961

Archives of Disease in Childhood

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It is apparent that, under certain circumstances so far undefined, neuroblastomata may be associated with a secretion of pressor amines in sufficient amounts to cause significant symptoms. Mason, Hart-Mercer, Millar, Strang and Wynne (1957) reported an infant with an adrenaline secreting intrathoracic neuroblastoma which was successfully removed. The preoperative symptoms, sweating and pallor, were completely relieved by extirpation of the tumour. We wish to report on a child in whom we were able to reach the correct diagnosis before operation by referring to the description by Mason and his colleagues. The symptomatology, situation and histology of the tumour and the postoperative course were similar to the infant described by Mason et al.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 94%

Functionally Active Intrathoracic Neuroblastoma

Ra¹,

Tp²,

Morris³

et al. 1961

Archives of Disease in Childhood

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“…In conclusion, we describe our experience with 24 children with SVCS treated at single institution over a 16 year period. Non-Hodgkin's lymphoma was the most frequent etiology of the mediastinal mass that occurred in the patients who initially presented with SVCS.…”

Section: Discussionmentioning

confidence: 97%

Superior vena cava syndrome associated with childhood malignancy: Analysis of 24 cases

Ingram

Rivera

Shapiro

1990

Med. Pediatr. Oncol.

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Twenty‐four children with superior vena cava obstruction at initial presentation or associated with disease recurrence were treated at St. Jude Children's Research Hospital from 1973 to 1988. Of the 16 patients with superior vena cava syndrome at presentation, eight had non‐Hodgkin's lymphoma, four had acute lymphoblastic leukemia, two had Hodgkin's disease, one had neuroblastoma, and one had a yolk sac tumor. Their clinical condition at presentation was often critical and required rapid treatment. In all cases, histopathologic diagnosis was obtained without complication by either bone marrow aspiration, lymph node biopsy, thoracentesis, or thoracotomy prior to the initiation of definitive therapy. Eight children had superior vena cava syndrome as a late complication during the course of their therapy. None had an antecedent history of superior vena cava obstruction. In contrast to the patients with superior vena cava obstruction at presentation, this group was composed predominantly of patients with recurrent solid tumors. Other causes included disseminated candidiasis and superior vena cava thrombosis, thus underscoring the importance of recognizing the etiology of superior vena cava syndrome to facilitate proper treatment.

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“…The Phaeochromocytoma 4--cell or cell Phaeochromocyte tumour may arise from undifferentiated sympathoblasts wherever sympathetic nervous tissue is found, the adrenal gland being the commonest site. Occasionally the tumour is primarily thoracic (this may have been so in Case 2); Ware (1956) collected 80 such cases from the literature and noted a high incidence of neurological complications. The late presentation of some of these tumours (as in Case 2) is interesting as 80% present before the age of 5 years (as in Cases and 3); exceptionally, the lesion may be present at birth.…”

Section: Discussionmentioning

confidence: 99%

Noradrenaline-secreting Neuroblastomata

Isaacs¹,

Medalie²,

Politzer³

1959

BMJ

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of sodium and aldosterone possessed by amphenone. Thyroid function also was not affected. SU 4885 is much the less toxic of the two drugs, gastric disturbances being the only consistent symptom. The excessive drowsiness which severely limits the use of amphenone did not occur.Although the action of SU 4885 on other adrenal steroids, notably oestrogens, has not yet been studied, the relatively large doses required to suppress hydrocortisone together with the formation of 1 l-deoxyhydrocortisone and probably deoxycortone do not indicate that this particular drug has immediate clinical application as an adrenal inhibitor. On the other hand, it seems likely that further compounds will be elaborated by means of which selective inhibition of adrenal enzyme systems may be satisfactorily achieved in patients.Summary The effect of a new adrenal inhibitory compound, SU 4885, has been studied in eight patients. Inhibition is directed particularly at adrenal steroid 1 1,3-hydroxylation, so that 11-deoxyhydrocortisone (compound S) and its urinary metabolite tetrahydro-S were found in relatively large quantities in blood and urine. In sufficient dosage, orally or intravenously, SU 4885 appeared capable of reducing the levels of hydrooortisone and its urinary metabolites.The toxicity of SU 4885 was significantly less than that of amphenone B.

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Thoracic neuroblastoma

Cited by 11 publications

References 33 publications

Functionally Active Intrathoracic Neuroblastoma

Functionally Active Intrathoracic Neuroblastoma

Superior vena cava syndrome associated with childhood malignancy: Analysis of 24 cases

Noradrenaline-secreting Neuroblastomata

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