Thoracic osteotomy for Gorham-Stout disease of the spine: a case report and literature review

Abstract

Level IV case report.

Left Functional Pneumonectomy Caused by a Very Rare Giant Intrathoracic Cystic Lesion in a Patient with Gorham–Stout Syndrome: Case Report and Review of the Literature

“…Pain is considered to be a frequent atypical symptom of GSS [ 64 ], mainly because of lymphangiomatous infiltration of bones. Maillot et al [ 67 ] state that vertebral primary involvement is rare (10%) and associated with a poor prognosis. However, patients tend to be undiagnosed until pathological fracture takes place even if localized pain is present [ 65 ].…”

Vanishing bone disease of chest wall and spine with kyphoscoliosis and neurological deficit: A case report and review of literature

“…Although the exact mechanism of this proliferation is not known, cytokines involved in angiogenic pathways such as platelet-derived growth factor, interleukin 6 (IL-6), vascular endothelial growth factor (VEGF), and lymphatic vessel endothelial hyaluronan receptor 1 may be involved. 8 Mechanical pressure caused by increased vascular tissue may be one of the causes of resorption of bone. Other mechanisms proposed are dysplasia of local lymphatic and blood vessels, primary aberration of vascular tissue due to granulation tissue in bone, and activation of local hydrolytic enzymes due to local hypoxia and acidosis induced by angiomatosis.…”

“…In addition to this, bisphosphonates may normalize serum levels of IL-6, thus reducing the osteoclastic activity. 8 Bisphosphonates have also shown to be having good analgesic effect. Bisphosphonates have not shown to cause bone formation in areas of osteolysis, but they have demonstrated efficacy in prevention of further resorption of bone and reduction of local symptoms.…”

“… 6 To the best of our knowledge, 13 cases of GD of spine have been reported after 2005. 8 20 21 22 23 24 25 26 27 28 29 30 31 A brief review of these cases with treatment and outcome has been shown in Table 2 . Out of the total 41 reported cases of GD of spine, cervical spine is the most commonly affected with 11 cases involving only cervical spine and additional 6 cases involving cervicothoracic spine.…”

Mandibular Gorham–Stout disease

“…The disease can be divided into an early stage with proliferation of intramedullary and cortical vessels, and a later stage characterized by destruction and resorption of bone. [ 9 ] The disease may be self-limiting over time or may lead to mortality if tissues such as craniofacial bones (cerebrospinal fluid leakage) or ribs (chylothorax) are involved. [ 1 ] This article describes a rare case of mandibular GSD.…”