Thoracic tuberculosis (TB) in 75 to 100 year-old patients

Garrido, Idoia Salinas; Huguet, Eva Tabernero; Garay, J. Garrós; Alaña, Pilar Gil; Ayuso, Esteban Ciruelos; Aranaga, Isabel Lopez; Basañez, Ramón Alkiza

doi:10.1183/13993003.congress-2016.pa2654

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large cohort study among Filipino immigrants to the United States found that one-third of individuals who developed TB after immigration had presented at entry with radiological findings consistent with previously active TB (72) consistent with the possibility that recurrence of TB (rather than reactivation of latent TB infection alone) might have contributed to the disease burden in this group. Furthermore, with decreasing incidence of TB in the general population, recurrent TB due to re-activation of old TB lesions in the elderly population (73,74) is expected to become a more 396 important cause of TB. The excess risk of TB associated with a past history of TB should 397 therefore be considered when tailoring target TB control measures to high-risk groups such as immigrants or the elderly, in order to achieve TB elimination.…”

Section: Moving Towards Tb Elimination In Low-incidence Settings -Howmentioning

confidence: 99%

Recurrent tuberculosis in the pre-elimination era

Rosser

Marx

Pareek

2018

int j tuberc lung dis

View full text Add to dashboard Cite

Recurrent tuberculosis (TB), defined as TB that recurs after a patient has been considered cured, constitutes a challenge to TB control. In low TB burden countries, the underlying causes and consequences of recurrent TB are poorly understood. We conducted a literature review to summarise the evidence of recurrent TB in low-burden settings and to address current gaps in knowledge. We included peer-reviewed publications on studies conducted in countries with an estimated TB incidence of <100 cases per 100 000 population. The Newcastle-Ottawa scale was used to assess study quality. The review yielded 44 manuscripts, 39 of which were reports of observational studies and 5 of clinical trials. The median percentage of TB patients experiencing an episode of recurrent TB after treatment completion was 3.4% (interquartile range [IQR] 1.6-6.0, range 0.4-16.7) in studies with a median follow-up of 7.8 years (IQR 5-12, range 2-33). The median percentage of recurrences attributable to endogenous reactivation (rather than exogenous reinfection) was 81% (IQR 73.1-85.5, range 49-100). Commonly identified risk factors for recurrence in low-burden settings included infection by the human immunodeficiency virus, low socio-economic status, foreign birth and infection with drug-resistant TB. Current understanding of recurrence in low-burden settings is limited, in part due to substantial methodological differences between studies. Further research is required to delineate the mechanisms of TB recurrence, its health and clinical impact, as well as the implications for TB elimination efforts in low-burden countries.

show abstract

Section: Moving Towards Tb Elimination In Low-incidence Settings -Howmentioning

confidence: 99%