Thoracic Wall Reconstruction for Primary Malignancies in Children: Short- and Long-term Results

Dingemann, Carmen; Linderkamp, Christin; Weidemann, Jürgen; Bataineh, Ziad; Ure, Benno M.; Nustede, R.

doi:10.1055/s-0031-1285873

Cited by 32 publications

(35 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Sabanathan et al 27 and Saenz et al 28 affirm the need for total resection of the affected rib together with the ribs immediately above and below in order to achieve a wide resection. Total rib resections are often associated with scoliosis 29,30 and reduction of lung function, 31 which is in accordance with our findings. Hayes et al 32 claim that only the involved ribs need to be resected, with Rao et al 33 and, more recently, Meys et al 34 drawing the same conclusions.…”

Section: Special Aspects Of Surgical Therapysupporting

confidence: 92%

Local Control in Ewing Sarcoma of the Chest Wall: Results of the EURO-EWING 99 Trial

et al. 2015

View full text Add to dashboard Cite

Background. Primary Ewing sarcoma (ES) can sometimes present as a chest-wall tumor. Multidisciplinary management, including chemotherapy and local treatment consisting of surgery, radiotherapy (RT), or both, has improved the survival of patients with localized ES; however, the best approach to achieving local control remains controversial.Methods. We retrospectively analyzed data from 198 patients with non-metastatic ES of the chest wall, who were registered in the database of the German Society of Pediatric Hematology and Oncology between July 1998 and April 2009. The majority of patients (n = 130) presented with rib tumors; 7 patients received RT only, 85 patients underwent surgery alone, and 106 patients were treated with a combination of surgery and RT. Results. Overall survival in all patients was 78 and 71 % at 3 and 5 years, respectively. Event-free survival at 5 years (5-year EFS) was 57 % in the RT group, 73 % in the surgery group and 63 % in the surgery ? RT group. In patients with complete resections, 5-year EFS did not improve with the addition of RT compared with surgery alone. There was no difference in the 5-year EFS in patients with partial (63 %) or total (64 %) resection of the affected ribs, and median follow-up was 4.71 years (range 0.40-13.48). Conclusions. Complete tumor resection is the best way to achieve local control of ES of the chest wall; additional RT is only useful in patients with incomplete resection. The main limitation of this study was its retrospective nature, and the benefit of total resection of the affected ribs could not be proved.Ewing sarcoma (ES) is a rare, highly malignant disease found in children, adolescents, and young adults, with a reported incidence of three persons per million people per year within a Caucasian population. Median age at diagnosis is 15 years, 1 and the chest wall is the primary site of presentation in 14 % of patients. The tumor most commonly originates from osseous structures (ribs 9 %, scapula 4 %, clavicle 1 %, or sternum \1 %), and even less frequently from the soft tissue of the chest wall (\1 %). 2 ESs of the chest wall have also been referred to as Askin's tumors, 3 until an identical molecular signature revealed a common origin.Multidisciplinary management has improved the 5-year survival of patients with localized disease to rates of 60-70 % and higher. 4-6 Multimodal therapy includes systemic therapy as well as surgery and radiotherapy (RT). 7 Until now, clinical trials on ES have principally focused on a comprehensive investigation of systemic treatment. 8-10 Although multi-agent chemotherapy is well defined as the standard of care for ES patients, the best approach for local control of ES of the chest wall remains a matter of discussion. 11 Local treatment of chest-wall tumors is often challenging, especially in young patients, as both local treatment modalities (surgery and RT) may be associated with significant long-term sequelae. 12 Due to the rarity of ES of the chest wall, only a limited number of patient series have been publis...

show abstract

Section: Special Aspects Of Surgical Therapysupporting

confidence: 92%

Local Control in Ewing Sarcoma of the Chest Wall: Results of the EURO-EWING 99 Trial

et al. 2015

View full text Add to dashboard Cite

show abstract

“…A 2006 report by Soyer et al [3] described 1 case of clinically significant scoliosis in a child undergoing primary tissue repair among 17 chest wall reconstructions performed using either primary repair, or Goretex, Dura, or Neuropatch prosthetics. Dingemann et al [4] followed with a report in 2011 of 8 patients undergoing reconstruction using synthetic mesh with or without titanium bar implantation for additional stabilization. Zero of the 8 patients developed clinically significant scoliosis using the diagnostic criteria applied to our series.…”

Section: Discussionmentioning

confidence: 99%

“…Historically, both tissue repair and synthetic mesh reconstruction have resulted in significant rates of progressive scoliosis and/or restrictive lung disease [1,2]. Contemporary case series describe improved results with new prosthetic materials and techniques, but the placement of permanent foreign bodies in children remains a concern [3,4].…”

mentioning

confidence: 99%

Chest wall reconstruction using implantable cross-linked porcine dermal collagen matrix (Permacol)

Lin

Kastenberg

Bruzoni

et al. 2012

Journal of Pediatric Surgery

View full text Add to dashboard Cite

“…The authors concluded that Surgisis is a preferable mesh option for chest wall reconstruction in children because they observed mesh constriction and the requirement for its removal owing to infection while they were using Goretex [3]. One recent case series reported their results of chest wall reconstruction owing to malignancy in 8 patients with a mean age of 10.6 years (range, 4.1-18.9 years) [18]. They found that the use of expanded Goretex soft tissue patches, absorbable Vicryl patches, and xenograft Tutopatch was safe and effective, but stabilization using titanium bars could be complicated by dislocation and require removal [18].…”

Section: Discussionmentioning

confidence: 99%

“…One recent case series reported their results of chest wall reconstruction owing to malignancy in 8 patients with a mean age of 10.6 years (range, 4.1-18.9 years) [18]. They found that the use of expanded Goretex soft tissue patches, absorbable Vicryl patches, and xenograft Tutopatch was safe and effective, but stabilization using titanium bars could be complicated by dislocation and require removal [18]. This is contradictory to the report by Smith and Campbell [3] that suggested the safety of titanium bars.…”

Section: Discussionmentioning

confidence: 99%

An innovative method of pediatric chest wall reconstruction using Surgisis and swinging rib technique

Oliveira

Zamakhshary

Alfadda

et al. 2012

Journal of Pediatric Surgery

View full text Add to dashboard Cite

Thoracic Wall Reconstruction for Primary Malignancies in Children: Short- and Long-term Results

Cited by 32 publications

References 17 publications

Local Control in Ewing Sarcoma of the Chest Wall: Results of the EURO-EWING 99 Trial

Local Control in Ewing Sarcoma of the Chest Wall: Results of the EURO-EWING 99 Trial

Chest wall reconstruction using implantable cross-linked porcine dermal collagen matrix (Permacol)

An innovative method of pediatric chest wall reconstruction using Surgisis and swinging rib technique

Contact Info

Product

Resources

About