Thoracoabdominal computed tomography neoplasia detection in patients with paraneoplastic pemphigus: the importance of collaboration between specialists

Abstract

The inclusion criteria were PNP diagnosis based on histological examination, serological tests, direct immunofluorescence microscopy, and thoracoabdominal CT performed at our hospital within 1 month after clinical suspicion of PNP. Patients with a previous neoplasm diagnosis were excluded. Following these criteria, 43 patients (mean age 59 years; range 39-78; 23 males) were included in the study. The study was approved by the institutional review board and ethics committee of our institution. Informed consent was obtained from all participants included in the study.According to Camisa et al., three major criteria, or two major and two minor criteria, are required to diagnose PNP (13,14). Major criteria include polymorphic mucocutaneous eruptions, concomitant internal neoplasm, and serum antibodies with a specific