Introduction: For a long time, the free or pedicled thoracodorsal artery perforator (TDAP) flaps were used for reconstruction of large cutaneous defects. These may be regional soft tissue defects of trunk, axilla and breast where the pedicled flap used, or distant tissue defects of face, elbow, forearm and lower extremity where the free TDAP flap is used. Aim of the Study: This study aimed to evaluate the clinical applications of the thoracodorsal artery perforator flap (TDAP) either free or pedicled in the reconstruction of soft tissue defects of extremities. Patients and Methods: This study was conducted on 20 patients admitted to the Plastic Surgery Departments of both Tanta & Al Azhar Universities during the period from September 2015 to December 2017. These patients were presented by extremity soft tissue defects that required a flap reconstruction. Results: The results showed that the TDAP flap is a versatile and robust flap in soft tissue reconstruction of the extremities. This flap has great advantages as a long vascular pedicle; large skin paddle can be harvested, minimal donor site morbidity and thin skin paddle to resurface shallow defects. The TDAP flap showed also some drawbacks like meticulous and time-consuming dissection of the perforators, donor site scar widening. Conclusion: TDAP flap is a versatile and an excellent flap either free or pedicled for extremity soft tissue reconstruction. It should be added to the workhorse perforator flaps.