Thoracoscopic Dorsal Sympathectomy for Upper Limb Buerger's Disease

Kothari, Reena; Sharma, Dhananjaya; Ds, Thakur; Kumar, Vishwajeet; Somashekar, Uday

doi:10.4293/108680813x13753907292755

Cited by 3 publications

(2 citation statements)

References 14 publications

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“…Complete healing was achieved in 61.9 % of the iloprost group and 41 % of the lumbar sympathectomy group at 4 weeks (P = .012) and in 85.3 versus 52.3 %, respectively, at 24 weeks (P G .001) [169]. Kothari et al recently reported that thoracoscopic dorsal sympathectomy reduces pain in patients with upper limb involvement in a recent case series of 25 TAO patients from India [170].…”

Section: Lumbar or Thoracic Sympathectomymentioning

confidence: 99%

Thromboangiitis Obliterans

Akar

İnan

Baran

2016

Curr Treat Options in Rheum

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Section: Lumbar or Thoracic Sympathectomymentioning

confidence: 99%

Thromboangiitis Obliterans

Akar

İnan

Baran

2016

Curr Treat Options in Rheum

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“…The limb involved is often characterized by skin chill, reduced or undetectable pulse, numbness, and intermittent claudication accompanied by migratory thrombophlebitis or superficial phlebitis. Ulcers or necrosis appear in serious cases (Kothari et al, 2014;Liu et al, 2014a;Yuan et al, 2014). As a vascular occlusive disease, the main pathogenesis of TO is ischemia and hypoxia.…”

Section: Introductionmentioning

confidence: 99%

Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans

He¹,

Qu²,

Wang³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. We investigated the expression and effects of hypoxiainducible factor-1α (HIF-1α) in rat thromboangiitis obliterans (TO). Rats were divided into sham and model groups. The model group was further divided into groups based on observation duration. Lauric acid was injected below an artery clamp to simulate TO in the model group; saline was used in the sham group. Clamps were removed 15 min after injection in both groups, and physiological changes were observed at different times (gross observation and hematoxylin and eosin staining). The animals were killed at various times following the operation and serum and muscle tissues were sampled. For the sham group: the endometrium was relatively intact; medial membrane and epineurium lesions were absent; and blood vessels and surrounding tissues had no inflammatory cell infiltration. For the model group: all subgroups displayed inflammation; large numbers of inflammatory cells were gathered; muscle tissue lost its normal texture and structure; and the internal elastic membrane was integrated. Compared with the preoperative status, HIF-1α expression increased significantly in all subgroups (P < 0.05); there was no change in the sham group. HIF-1α expression in each subgroup was different (F = 14.267, P < 0.05). Femoral artery injection of lauric acid can be used as T. He et al. 6716©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (2): 6715-6722 (2015) a rat TO model owing to its simple application and success rate. HIF-1α expression increased in the early stage of TO and gradually decreased with the extension of ischemia time; it may play a leading role in TO development and can be used for diagnosis and cure evaluation.

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Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research

Wang²,

Yang

et al. 2020

CMC

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Background:: Thromboangiitis obliterans (TAO) is a nonatherosclerotic thrombotic-occlusive vasculitis that affects the vessels of the small and medium sized extremities. No explicit etiology or pathogenesis of TAO has been proven, and more effective treatments are needed. Objective: : To summarize and present an overview of recent advances regarding the risk factors, mechanisms and treatments of TAO and to organize the related information into figures to provide a comparatively complete reference. Methods:: We searched PubMed for English-language literature about TAO without article type limits, including articles about the risk factors, pathological mechanisms and treatments of TAO in the last 10 years with essential supplements (references over ranges and English abstracts of Russian literature). Results:: After screening content of literatures, 99 references were evaluated. We found that risk factors of TAO include smoking, gene factors and periodontal diseases. The underlying mechanism of TAO involves in oxidative stress, immunity, hemodynamic changes, inflammation and so on. Moreover, similarities in genetic factors and cigarette relevance existed between periodontal diseases and TAO, so further relationship study of them are required. For TAO treatment, medicine, endovascular intervention and revascularization surgery, autologous cell therapy and novel therapies were also mentioned. Besides, a hypothesis that infection triggers autoimmunity in TAO could be speculated, in which TLR4 plays a key role. Conclusions:: 1. Puts forward a hypothesis that infections can trigger autoimmunity in TAO development, in which TLR4, as a key role, can activate immune signaling pathways and induce autoimmune cytokines expression. 2. Suggests a reconsideration about the association between periodontal diseases and TAO, such as they just share the same high-risk population. Controlling periodontal disease severity in TAO studies may provide new clues. 3. For TAO treatment, endovascular intervention and autologous cell therapy both showed promising long-term therapeutic effectiveness, in which autologous cell therapy is becoming more popular, although more clinical comparisons needed.

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Thoracoscopic Dorsal Sympathectomy for Upper Limb Buerger's Disease

Cited by 3 publications

References 14 publications

Thromboangiitis Obliterans

Thromboangiitis Obliterans

Hypoxia-inducible factor-1α expression in the different stages of rat thromboangiitis obliterans

Risk Factors, Mechanisms and Treatments of Thromboangiitis Obliterans: An Overview of Recent Research

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