Thoracoscopic pleurodesis using talc poudrage versus cytotoxic drug in malignant pleural effusion: narrative review

Loizzi, Domenico; Sollitto, Francesco; Piazzolla, Michele; Ardò, Nicoletta Pia

doi:10.21037/jxym-20-67

Cited by 5 publications

(13 citation statements)

References 51 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This procedure involves introducing a sclerosing agent into the pleural cavity to trigger an inflammatory response, leading to pleural adhesion and fibrosis. This process of obliterating the pleural cavity helps prevent MPE recurrence [ 4 ]. A variety of chemical agents can be used for pleurodesis, but a definitive consensus on the best agent has yet to be reached.…”

Section: Discussionmentioning

confidence: 99%

“…The effectiveness of chemical pleurodesis varies depending on the agent and procedure employed, making the selection of a safe and effective combination of agent and procedure critical [ 5 ]. Talc is the preferred agent according to international guidelines [ 4 ], and its superiority over alternative agents has been reported in multiple studies [ 6 - 8 ]. Additionally, previous analyses have indicated potential benefits of surgical procedures, such as a more uniform distribution of the agent [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…We assessed the patient’s pain score and body temperature 4 hours after the procedure. We considered pleurodesis to be effective if pleural effusion did not recur within 4 weeks [ 4 ]. We removed the chest tube when the drainage fell below 200 mL per day.…”

Section: Methodsmentioning

confidence: 99%

“…Both agents can be administered through either surgical or bedside procedures. However, it is known that talc, when applied via a surgical procedure, can provide outcomes that are at least equivalent to, if not more effective than, those achieved with the bedside procedure in certain disease groups [ 4 ]. The findings of this study could suggest a more effective and less invasive method for achieving optimal pleurodesis.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Which is the More Effective Option for Pleurodesis to Prevent the Recurrence of Malignant Pleural Effusion? Large-Particle Talc or Mistletoe Extract (ABNOVA Viscum Injection)

et al. 2023

View full text Add to dashboard Cite

Background Malignant pleural effusion affects many patients with advanced cancer. When chemotherapy or radiotherapy fails to relieve malignant pleural effusion and related symptoms, drainage and pleurodesis can help. Although surgical talc pleurodesis is the most widely used method, Viscum album , which has been recently used in surgical or bedside procedures, has demonstrated significant results and is as effective as talc. This study aimed to determine the most effective agent and procedure. Methods Between January 2015 and July 2022, chemical pleurodesis was performed in 137 patients with malignant pleural effusion, using a V. album surgical procedure in 48, a V. album bedside procedure in 55, and a talc surgical procedure in 34 patients. We reviewed patients’ clinical responses and disease progression after chemical pleurodesis. Results The success rate was not significantly different among the V. album surgical procedures (91.7%), V. album bedside procedures (83.6%), and talc surgical procedures (91.2%). However, the total drainage amount and tube insertion duration in both Viscum groups were more effective than those in the talc group. Furthermore, the bedside Viscum group showed significantly lower post-pleurodesis pain scores than the other 2 groups. Conclusion According to our results, talc and V. album can be considered ideal agents for chemical pleurodesis. However, Viscum pleurodesis showed safer outcomes in terms of ensuring quality of life than talc. Additionally, the bedside Viscum group showed significantly lower pain scores than the other groups. Hence, patients for whom surgical procedures are inappropriate can undergo bedside Viscum pleurodesis without diminishing the therapeutic effect.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Which is the More Effective Option for Pleurodesis to Prevent the Recurrence of Malignant Pleural Effusion? Large-Particle Talc or Mistletoe Extract (ABNOVA Viscum Injection)

et al. 2023

View full text Add to dashboard Cite

show abstract

“…As chemical pleurodesis treatment we preferred to use betadine over talc. The literature warns against significant side effects in using chemical pleurodesis with talc, such as fever, chest pain [20], cough, infection at the insertion of the drain, bronchospasm, allergic reaction, arrhythmias, pulmonary edema, pneumonia, respiratory failure, and acute respiratory distress syndrome [21,22]. Other studies found even more disadvantages of talc chemical pleurodesis in malignancies, such as fixation of the lung parenchyma at the level of the pleuropericardial window, which causes pericardial constriction [23,24].…”

Section: Discussionmentioning

confidence: 99%

The Association of Minimally Invasive Surgical Approaches and Mortality in Patients with Malignant Pleuropericarditis—A 10 Year Retrospective Observational Study

Nistor¹,

Găvan²,

Ciritel

et al. 2022

Medicina

View full text Add to dashboard Cite

Background and Objectives: Malignant neoplasms are common causes of acute pleuropericardial effusion. Pleuropericarditis denotes poor patient prognosis, is associated with shortened average survival time, and represents a surgical emergency. Materials and Methods: We analyzed the impact of two minimally invasive surgical approaches, the type of cancer, and other clinical variables on the mortality of 338 patients with pleuropericarditis admitted to an emergency hospital in Romania between 2009 and 2020. All patients underwent minimally invasive surgeries to prevent the recurrence of the disease and to increase their life expectancy. Log-rank tests were used to check for survival probability differences by surgical approach. We also applied univariate and multivariate Cox proportional hazard models to assess the effect of each covariate. Results: No significant differences were found in the 2-year overall survival rate between patients who underwent the two types of surgery. The multivariate Cox proportional regression model adjusted for relevant covariates showed that age, having lung cancer, and a diagnosis of pericarditis and right pleural effusion increased the mortality risk. The surgical approach was not associated with mortality in these patients. Conclusion: These findings open up avenues for future research to advance the understanding of survival among patients with pleuropericarditis.

show abstract

Advancing steel protection with Ceria@Talc-8-hydroxyquinoline modified Polyurethane coatings

Habib,

Qureshi,

Faisal

et al. 2024

Progress in Organic Coatings

View full text Add to dashboard Cite

Thoracoscopic pleurodesis using talc poudrage versus cytotoxic drug in malignant pleural effusion: narrative review

Cited by 5 publications

References 51 publications

Which is the More Effective Option for Pleurodesis to Prevent the Recurrence of Malignant Pleural Effusion? Large-Particle Talc or Mistletoe Extract (ABNOVA Viscum Injection)

Which is the More Effective Option for Pleurodesis to Prevent the Recurrence of Malignant Pleural Effusion? Large-Particle Talc or Mistletoe Extract (ABNOVA Viscum Injection)

The Association of Minimally Invasive Surgical Approaches and Mortality in Patients with Malignant Pleuropericarditis—A 10 Year Retrospective Observational Study

Advancing steel protection with Ceria@Talc-8-hydroxyquinoline modified Polyurethane coatings

Contact Info

Product

Resources

About