Thoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancer

Horie, Kazumasa; Oshikiri, Taro; Kitamura, Yu; Shimizu, Masaki; Yamazaki, Yuta; Sakamoto, Hiroki; Ishida, Sonoko; Koterazawa, Yasufumi; Ikeda, Taro; Yamamoto, Masashi; Kanaji, Shingo; Matsuda, Yoshiko; Yamashita, Kimihiro; Matsuda, Takeru; Suzuki, Satoshi; Kakeji, Yoshihiro

doi:10.1111/ases.12757

Cited by 14 publications

(16 citation statements)

References 15 publications

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“…Among malignant tumors, gastric cancer is a common digestive system tumor, and its main treatment methods are surgery and systemic chemotherapy. 13,14 However, since most patients were at late stage when they are diagnosed, they have lost the opportunity of surgery and can only be treated with chemotherapy. Due to the existence of drug resistance to chemotherapy, many patients will suffer from poor or even ineffective treatment, which will further aggravate the disease.…”

Section: Discussionmentioning

confidence: 99%

<p>Promotion of miR-221-5p on the Sensitivity of Gastric Cancer Cells to Cisplatin and Its Effects on Cell Proliferation and Apoptosis by Regulating DDR1</p>

Jiang

Guo

et al. 2020

OTT

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Purpose: This research aimed to explore the role of miR-221-5p on the sensitivity of gastric cancer cells to cisplatin, and the proliferation and invasion of gastric cancer cells by regulating DDR1. Patients and Methods: Altogether 69 patients who treated with radical gastrectomy from January 2014 to January 2016 were collected. With the agree of the patients, 69 gastric carcinoma and 69 adjacent tissues were taken, respectively, during the operation, and gastric carcinoma and human gastric mucosa cells were purchased. RT-PCR was used for detection of the expression level of miR-221-5p and DDR1. Wound healing assay and CCK-8 assay were used for exploration of the cell migration and viability. Western blot and double luciferase reporter gene were performed to determine the target gene of miR-221-5p. Results: It was showed that miR-221-5p expression was decreased in GC tissues and cell lines. The high expression of miR-221-5p reduced the resistance of GC cells to cisplatin and inhibited the proliferation and migration of gastric cancer cells. The high expression of miR-221-5p promoted the proliferation, invasion and migration of GC cells. In addition, we found that DDR1 was a direct target gene of miR-221-5p in GC cells. We found that DDR1 expression increased in gastric carcinoma. Moreover, there was a negative correlation of DDR1 with the expression level of miR-221-5p. The increase of miR-221-5p increased the chemosensitivity of GC cells to cisplatin, and inhibited the proliferation, invasion, migration and EMT of GC cells by targeting DDR1. Conclusion: The above research indicated that miR-221-5p may be a target for enhancing cisplatin chemotherapy sensitivity in gastric cancer patients.

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Section: Discussionmentioning

confidence: 99%

<p>Promotion of miR-221-5p on the Sensitivity of Gastric Cancer Cells to Cisplatin and Its Effects on Cell Proliferation and Apoptosis by Regulating DDR1</p>

Jiang

Guo

et al. 2020

OTT

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“…Ultimately, the optimal surgical approach depends on the case. If necessary, the left thoracic approach reported by Horie et al should be considered 5 . Despite a few concerns, our laparoscopic mediastinal approach is a viable treatment option for gastric conduit cancer.…”

Section: Discussionmentioning

confidence: 95%

“…The retrosternal route is a common reconstruction method. However, gastric conduit cancer surgery through the retrosternal route is often too invasive because sternotomy is usually required, causing lethal osteomyelitis 5 . Therefore, avoiding sternotomy is very important in performing gastric conduit cancer surgery through the retrosternal route.…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic mediastinal approach for retrosternal gastric conduit cancer after esophagectomy

Hayashi

Fujita

Matsushita

2020

Asian J Endoscop Surgery

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The prognosis of esophageal cancer has improved, but the incidence of gastric conduit cancer has increased. Gastric conduit cancer is difficult to treat because current treatment options are highly invasive; in particular, surgical procedures have high mortality and modality. Treatment through the retrosternal route usually requires sternotomy, which often causes lethal osteomyelitis. To prevent lethal complications and reduce invasiveness, we used the laparoscopic mediastinal approach. Here, we report a successful case using the laparoscopic mediastinal approach for the treatment of gastric conduit cancer through the retrosternal route. Despite a few concerns, this approach can be a treatment option for gastric conduit cancer through the retrosternal route.

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“…In patients with gastric tube cancer reconstructed through the retrosternal route, a median sternotomy is often performed 6 , 7 , 8 ; however, this procedure is invasive and has the risk of severe complications, including sternal dehiscence or mediastinitis. 7 , 9 …”

Section: Introductionmentioning

confidence: 99%

“…Recently, although there have been some reports of procedures without a median sternotomy for patients with retrosternal gastric tube cancer, nearly all of the reports only involve single cases. 7 , 8 , 9 , 10 …”

Section: Introductionmentioning

confidence: 99%

A novel laparoscopic assisted mediastinal dissection with gastric tube inversion technique for gastric tube cancer reconstructed through a retrosternal route

Numata

Higaki

et al. 2021

Annals of Gastroent Surgery

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A median sternotomy is often performed in patients with gastric tube cancer reconstructed through the retrosternal route; however, this procedure is invasive and has the risk of severe infectious complications. To overcome these problems, we created a novel method to perform the reconstructed gastric tube resection using a gastric tube inversion technique combined with a laparoscopic mediastinal approach. After the duodenum was divided, the oral side of the cut end was sutured with silken threads for traction. The gastric tube was dissected from the caudal side under a laparoscopic mediastinal approach, whereas the cervical esophagus was taped. After the adhesion between the middle side of the posterior sternum and the reconstructed gastric tube was dissected to the cervix, the gastric tube was inverted by guiding and pulling the thread toward the cervical side. Sharp dissection was facilitated between the inverted gastric tube and the surrounding organs under moderate traction and a favorable surgical view. We have performed this procedure and evaluated the short‐term outcomes in six cases. The laparoscopic mediastinal approach was completed without a median sternotomy in all six cases. Restorable intraoperative lung injury was observed in one case and no major vessel injuries were observed. The postoperative course was satisfactory with a 29.5‐day median length of hospital stay (range, 16‐60 days). The gastric tube inversion technique combined with the laparoscopic mediastinal approach for patients with retrosternal‐reconstructed gastric tube cancer was shown to be safe and less invasive and should be considered in resection of the reconstructed gastric tube.

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Thoracoscopic retrosternal gastric conduit resection in the supine position for gastric tube cancer

Abstract: This article may be used for noncommercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.

Cited by 14 publications

References 15 publications

<p>Promotion of miR-221-5p on the Sensitivity of Gastric Cancer Cells to Cisplatin and Its Effects on Cell Proliferation and Apoptosis by Regulating DDR1</p>

<p>Promotion of miR-221-5p on the Sensitivity of Gastric Cancer Cells to Cisplatin and Its Effects on Cell Proliferation and Apoptosis by Regulating DDR1</p>

Laparoscopic mediastinal approach for retrosternal gastric conduit cancer after esophagectomy

A novel laparoscopic assisted mediastinal dissection with gastric tube inversion technique for gastric tube cancer reconstructed through a retrosternal route

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