loss leads to a broad spectrum of complications, from acute cardiac tamponade to subacute hemothorax. Boyle et al. described the need for new labels for post-surgical bleeding, including the acute, subacute, and chronic phases of bleeding, and proposed the term retained blood syndrome (RBS).3) The incidence of RBS is 13.8%-22.7% after cardiac surgery. 3) In acute RBS, early exploration within the first 48 postoperative hours via an emergency re-sternotomy is the gold standard. In subacute RBS (>48 hr), the remaining clots activate inflammatory mechanisms that cause increased postoperative atrial fibrillation, in-hospital mortality, and longer in-hospital stays. 4) In addition, a large number of clots cause mechanical compression of the lung and severe atelectasis. Furthermore, clot contamination can lead to pleural empyema. 5) Despite the consequences, proper management of subacute Purpose: Blood loss along with inadequate evacuation after cardiac surgery leads to retained blood syndrome (RBS) in the pleural and/or pericardial cavity. Re-sternotomy is often needed for clot evacuation. Video-assisted thoracoscopic surgery (VATS) evacuation is a less-invasive procedure. However, sufficient evidence on safety and outcomes is lacking. Methods: Thirty patients who developed hemothorax and/or hemopericardium after cardiac surgery and underwent VATS evacuation between April 2015 and September 2020 were included in this retrospective single-center analysis. Results: The median patient age was 70 (interquartile range: IQR 62-75) years, body mass index (BMI) was 24.7 (IQR 22.8-29) kg/m 2 , time between initial cardiac surgery and VATS was 17 (IQR 11-21) days, 30% of the patients were female, 60% resided in the ICU, and 17% were nicotine users. Coronary artery bypass graft was the most frequent initial cardiac procedure. Median operation time was 120 (IQR 90-143) min, 23% of the patients needed an additional VATS, and the median length of hospital stay after VATS was 8 (IQR 5-14) days. All patients survived VATS, and we experienced no mortality related to the VATS procedure. Conclusion: In our study, VATS for evacuation of RBS after cardiac surgery was a feasible, safe, and efficient alternative approach to re-sternotomy in selected patients.