The rapid development of a new generation of information technology has caused major changes in teaching and learning methods, promoted the innovation and transformation of education informatization, and promoted the realization of education modernization. Education informatization has gradually become one of the core factors that determine the quality of education. There is a close connection with the regional economy. The western region of my country (mainly including the mountainous areas in the southwest and the arid areas in the northwest) shows regional characteristics such as fragile ecological environment, lagging economic development, and large gaps in infrastructure and public services. Informatization of education is urgently needed to promote regional economic development. By comparing the gross product and educational expenditure of Zhejiang province and Gansu Province, this paper concludes the interdependence and mutual promotion between the development of educational informationization and regional economic development. On this basis, this paper analyzes the necessity of the informationization of education and the coordinated development of regional economy in the ecologically fragile areas of western China. Finally, from five aspects, it puts forward an effective way to promote the development of education informatization and regional economy, aiming at realizing the coordinated development of education informatization and regional economy. Finally improve the social productivity of western region and our country's comprehensive national strength.