Thoughts on What Chemists Can Contribute to Fighting SARS‐CoV‐2 – A Short Note on Hand Sanitizers, Drug Candidates and Outreach

Opatz, Till; Senn‐Bilfinger, Joerg; Richert, Clemens

doi:10.1002/ange.202004721

Cited by 8 publications

(1 citation statement)

References 33 publications

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“…It was not so long ago when the COVID-19 pandemic changed overnight numerous aspects of our everyday life we have considered guaranteed. Increasing awareness of the global population and escalating demand for hand sanitisation products during the pandemic resulted in temporary supply shortages, increasing raw materials prices, and a search for homemade alternatives to traditional handwashing in regions with limited water access 2 . In the following years, we have accepted the omnipresence of hand-sanitising stations scattered around heavily populated urban areas.…”

Section: Introductionmentioning

confidence: 99%

Development of spray-dried powder hand sanitiser with prolonged effectivity

Večerková,

Mašková,

Knejzlík

et al. 2024

Sci Rep

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Since the outbreak of the COVID-19 pandemic, the use of hand sanitisers has become an inseparable part of our personal hygiene. However, the short-term effect and the need for frequent application are shortcomings that impair the overall protection. Another aspect is that repeated use of some products (typically alcohol-based) may cause skin irritation or eventually more severe health problems. This work proposes spray-drying as a suitable method for the preparation of swellable chitosan carriers, allowing for encapsulation and sustained release of antibacterial chlorhexidine digluconate as a model active substance. After application to hands, micron-sized particles preferentially accommodate space between epidermal ridges, protected against attrition. Thanks to their small size (d < 10 µm), particles are comfortable to carry since they are not recognisable by somatosensory receptors. The performance of formulations with various amounts of chlorhexidine and cross-linker was tested and compared with selected commercial disinfectants available on the Czech market (ethanol gel and alcoholic solution with chlorhexidine) against E.coli and S.epidermidis. The real-life performance was investigated with twelve volunteers performing various activities for up to 2 h. Finally, a replica of the human index finger with accurately captured micro-topology was proposed and compared with volunteers’ fingers concerning the total amount of adhered and detached particles.

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Section: Introductionmentioning

confidence: 99%

Development of spray-dried powder hand sanitiser with prolonged effectivity

Večerková,

Mašková,

Knejzlík

et al. 2024

Sci Rep

View full text Add to dashboard Cite

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Re‐imagining Priorities for Chemistry: A Central Science for “Freedom from Fear and Want”

et al. 2021

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Human security,defined as "freedom from want and fear and freedom to live in dignity", provides an overarching concept to address threats to human security dimensions such as health, food, economics,t he environment and sustainable development, while placing the individual at the centre of attention. Chemistry is central to addressing these challenges, but surprisingly its role and contributions to human security have hitherto not been explicitly set out. This article situates chemistry in the human security framework, highlighting areas where chemistry knowledge,methods and products are vital. It underscores three complementary facets:1)chemistry contributes to many dimensions of human security,b ut needs to do muchm ore in the light of oncoming global challenges;2 )the human security framing illuminates areas where chemistry itself needs to adapt to contribute better,b yi ntensification of current approaches and/or by building or strengthening chemistry tools,s kills and competencies;a nd 3) repositioning as central to human security affords chemistry ap owerful opportunity to refresh itself as as cience for the benefit of society-and it will need to engage more directly and dynamically at the interface of science,s ociety and policy in order to do so.Noshiftinthewaywethinkoractismorecriticalthanthatof putting people at the centre of everything we do.T hat is the essence of human security.

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Assembly of Hexagonal Column Interpenetrated Spheres from Plant Polyphenol/Cationic Surfactants and Their Application as Antimicrobial Molecular Banks

Shen

et al. 2021

Angewandte Chemie

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Microbial infections have become a great threat to human health and one of the main risks arises from direct contact with the surfaces contaminated by pathogenic microbes. Herein, a kind of hexagonal column interpenetrated spheres (HCISs) are fabricated by non‐covalent assembly of plant gallic acid with quaternary ammonium surfactants. Different from one‐time burst release of conventional antimicrobial agents, the HCIS acts like a “antimicrobial molecular bank” and releases the antimicrobial ingredients in a multistage way, leading to long‐lasting antimicrobial performance. Taking advantage of strong hydrophobicity and adhesion, HCISs are applicable to various substrates and endowed with anti‐water washing property, thus showing high in vitro antimicrobial efficiency (>99 %) even after being used for 10 cycles. Meanwhile, HCISs exhibit broad‐spectrum antimicrobial activity against bacteria and fungi, and have good biocompatibility with mammalian cells. Such a low‐cost and portable long‐lasting antimicrobial agent meets the growing anti‐infection demand in public spaces.

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Thoughts on What Chemists Can Contribute to Fighting SARS‐CoV‐2 – A Short Note on Hand Sanitizers, Drug Candidates and Outreach

Cited by 8 publications

References 33 publications

Development of spray-dried powder hand sanitiser with prolonged effectivity

Development of spray-dried powder hand sanitiser with prolonged effectivity

Re‐imagining Priorities for Chemistry: A Central Science for “Freedom from Fear and Want”

Assembly of Hexagonal Column Interpenetrated Spheres from Plant Polyphenol/Cationic Surfactants and Their Application as Antimicrobial Molecular Banks

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