The basic purpose of this study is "to analyse different safety and security measures in both public and private schools at secondary level in Islamabad." The study was conducted in Islamabad; therefore all the heads of schools constituted as the population of this study. In the sample the number of public schools were 50 and private were also 50. The numbers of male heads of the schools were 56 and female were 44. Checklist for Comparative Analysis of Safety and Security Measures at Secondary level was used to collect the data. It consists of 35 items. Heads of schools responded to the items in three ways either as "Yes" or "No" and further action needed. The findings of this study shows that safety and security measures such as flooring and lighting; number of furniture according to the number of users, stable portable equipment i.e. TV and Computers, good practice of computers among students; fire-fighting equipment, fire evacuation procedures, the evacuation drill; testing of water samples, Remedial actions against exceed limits for bacteria, cold water is used for preparing foods and beverages; emission inspection stickers; Natural disasters, Fires, Chemical or hazardous material spills or releases, Major transportation accidents, Incidents of violence, Bomb threats and acts of terror are most common measure in both public and private school at secondary level. Both male and female heads as well as public and private schools heads had no significant mean differences regarding safety and security measures at secondary level schools in Islamabad, Pakistan.