Chemical, biological, radiological, nuclear, and explosive devices can all be used to cause mass disruption and mass casualties. These incidents can occur naturally but are usually associated with terrorism and often require prehospital and hospital care for patients and various precautions for clinicians. It is important to consider for each kind of exposure how clinical and ethical demand for rescue should be balanced against field-based risk of injury, contamination, or death to tactical personnel. Chemical exposures typically require prompt extrication, decontamination, and medical management; biological and radiation exposures generally require donning personal protective equipment; and explosives could contain "dirty bombs" or secondary devices.Hazardous Exposures Chemical, biological, radiological, nuclear, and explosive (CBRNE) devices can all cause mass disruption and lead to massive numbers of casualties. These events, frequently referred to as CBRNE incidents, may be of natural or man-made origin. In the early phases of medical response to these incidents, prehospital personnel (first responders) and in-hospital personnel (first receivers) are the initial contacts for medical care of the victims involved in CBRNE incidents who are triaged at the scene or who self-present to a health care facility. 1 Difficult decisions often need to be made and should be informed by the ethical and clinical implications of possible courses of action that were discussed with highly trained personnel during the planning phases of disaster response. 2,3 The degree and duration of management efforts will often be determined by the type of exposure and the capacity of the health care delivery system. In this article, we discuss the inherent danger posed by such incidents to both prehospital and hospital personnel and the care dilemmas that arise as overburdened health care delivery systems must consider shifting from what some would argue is "crisis standards of care" 4,5 to "altered standard of care" 6 to allow for any contingency or crisis plan to be successfully implemented. 7 Risks to Personnel Chemical exposure. CBRNE incidents involving chemical exposure, though varying widely in their treatment, require immediate identification, decontamination, and prompt