Threatened abortion, threatened premature labor, and preterm birth during the first state of emergency for <scp>COVID</scp>‐19 in 2020 in Japan

Okawa, Sumiyo; Hosokawa, Yoshihiko; Nanishi, Keiko; Zaitsu, Masayoshi; Tabuchi, Takahiro

doi:10.1111/jog.15203

Cited by 15 publications

(12 citation statements)

References 30 publications

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“…Our result is consistent with a previous report of decreased preterm birth during the pandemic in high-income countries 16 . Although another study also reported that the prevalence of TPL and preterm birth decreased during and after the state of emergency in Japan, we also demonstrated improved outcomes of neonatal complications based on a larger sample size compared to the previous study 17 . Furthermore, our study showed oral ritodrine hydrochloride usage in all the participants significantly decreased during the COVID-19 pandemic.…”

Section: Discussioncontrasting

confidence: 43%

Amelioration of prevalence of threatened preterm labor during the COVID-19 pandemic: nationwide database analysis in Japan

Ohashi

Tsuji

Tanaka‐Mizuno

et al. 2022

Sci Rep

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We aimed to evaluate the changes in maternal and neonatal complications such as threatened preterm labor (TPL) and preterm birth before and during the coronavirus disease 2019 (COVID-19) pandemic using large-scale real-world data in Japan. We obtained data from the Japan Medical Data Center claims database and evaluated differences in maternal and neonatal complications, such as the prevalence of TPL and preterm birth before the COVID-19 pandemic (in the year 2018 or 2019) and during the COVID-19 pandemic (in 2020). We included 5533, 6257, and 5956 deliveries in the years 2018, 2019, and 2020, respectively. TPL prevalence and preterm birth had significantly decreased in 2020 (41.3%, 2.6%, respectively) compared with those reported in 2018 (45.3%, 3.9%, respectively) and 2019 (44.5%, 3.8%, respectively). Neonatal outcomes such as low-birth-weight infants and retinopathy of prematurity were also improved during the pandemic. There were no clear trends in the prevalence of maternal complications such as hypertensive disorders of pregnancy; hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome; and preeclampsia. Oral ritodrine hydrochloride usage in all participants had significantly decreased during the COVID-19 pandemic. In conclusion, our results suggest that the COVID-19 pandemic has ameliorated TPL and consequently reduced the number of preterm births.

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Section: Discussioncontrasting

confidence: 43%

Amelioration of prevalence of threatened preterm labor during the COVID-19 pandemic: nationwide database analysis in Japan

Ohashi

Tsuji

Tanaka‐Mizuno

et al. 2022

Sci Rep

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“…In this nationwide, cross‐sectional study, we used data of postpartum mother–infant pairs from the Japan COVID‐19 and Society Internet Survey (JACSIS) (https://jacsis-study.jp/). The JACSIS gathers data from the pooled panels of an internet research agency (Rakuten Insight, Inc. [https://insight.rakuten.co.jp/], which has approximately 2.3 million panelists currently); details of the JACSIS, quality controls, and other policies for panelists have been described previously 6,19,20 . Briefly, the JACSIS consists of three internet‐based survey panels of (a) young people and adults aged 15–79 years, (b) pregnant/postpartum mothers and fetus/infant pairs, and (c) adults living in a single‐parent household.…”

Section: Methodsmentioning

confidence: 99%

“…The JACSIS gathers data from the pooled panels of an internet research agency (Rakuten Insight, Inc. [https://insig ht.rakut en.co.jp/], which has approximately 2.3 million panelists currently); details of the JACSIS, quality controls, and other policies for panelists have been described previously. 6,19,20 Briefly, the JACSIS consists of three internet-based survey panels of (a) young people and adults aged 15-79 years, (b) pregnant/postpartum mothers and fetus/infant pairs, and (c) adults living in a single-parent household. In this study, we exclusively used data from the panel of postpartum mother-infant pairs, in which the age and geographical distributions were nationally representative.…”

Section: Study Design Data Setting and Participantsmentioning

confidence: 99%

Maternal heated tobacco product use during pregnancy and allergy in offspring

Zaitsu

Kono

Hosokawa

et al. 2022

Allergy

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Background:Little is known about the association between maternal use of heated tobacco products (HTPs) during pregnancy and the onset of allergy among offspring.This study aimed to determine whether maternal HTP smoking is associated with allergy in their offspring and to evaluate the potential dose-response association.Methods: In this web-based, cross-sectional survey conducted in July and August 2021 in Japan, we investigated 5688 pairs of postpartum women and infants (<3 years). Clinical diagnoses of infant asthma, rhinitis, conjunctivitis, or atopic dermatitis were reported. Using multilevel Poisson regression, we estimated the prevalence ratios (PRs) and 95% confidence intervals (CIs) of allergy in infants with HTP smoking categories cross-classified by pregnancy periods, and adjusted for potential covariates including maternal cigarette smoking and partner's smoking status. Non-smokers served as the reference group. Results:In total, 2.4% women smoked HTPs during pregnancy. Allergy occurred in 7.8% of the infants. The prevalence of allergy increased among the offspring of current HTP smokers during pregnancy at 15.2% (PR = 1.98, 95% CI 1.28-3.05); this association was the most pronounced during the first trimester but attenuated before pregnancy and postpartum. Dose-response associations were observed, for example a one-unit increase in daily maternal HTP use during pregnancy was associated with a 5% increase in allergy onset. Sub-group analyses excluding cigarette smokers during pregnancy and sensitivity analyses using the International Study of Asthma and Allergies in Childhood questionnaire showed a similar pattern.Conclusions: Maternal HTP smoking during pregnancy is associated with allergy in the offspring.

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“…The sample size of 1,000 was decided based on feasibility to conduct the research. Details of the sampling strategy are described elsewhere ( Okawa et al, 2022 ).…”

Section: Methodsmentioning

confidence: 99%

Influence of the COVID-19 pandemic on breastfeeding support for healthy mothers and the association between compliance with WHO recommendations for breastfeeding support and exclusive breastfeeding in Japan

Nanishi

Okawa

Hongo

et al. 2022

PeerJ

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Background Professional breastfeeding support contributes to maternal and child health. However, the influence of the current coronavirus disease 2019 (COVID-19) pandemic on breastfeeding support has not been carefully examined. Therefore, we assessed maternal breastfeeding intention and professional breastfeeding support before and during the pandemic. We further examined the association of compliance with World Health Organization (WHO) recommendations for professional breastfeeding support with exclusive breastfeeding during the pandemic. Methods This cross-sectional, internet-based, questionnaire study analyzed data from 484 healthy women with live singleton births between 15 October 2019 and 25 October 2020 in Japan. A delivery before 5 March 2020 was classified as a before-pandemic delivery (n = 135), and a delivery after 6 March 2020 was a during-pandemic delivery (n = 349). Among the ten breastfeeding support steps recommended by the WHO, we assessed the five steps that are measurable by maternal self-report and would likely exhibit variability. Receipt of a free formula sample or invitation to a free sample campaign by the time of survey was also asked. Infant feeding status at the time of the survey was measured among women with infants younger than 5 months, which was a subgroup of mothers who delivered during the pandemic. Mothers were asked what was given to infants during the 24 h before the survey and when nothing other than breast milk was given, the status was classified as exclusive breastfeeding. Results While 82.2% of women with a delivery before the pandemic intended to breastfeed, the rate was 75.6% during the pandemic (p = 0.120). The average number of breastfeeding support steps received was 3.24 before the pandemic but it was 3.01 during the pandemic (p = 0.069). In particular, rooming-in was less frequent (39.3% before vs. 27.8% during the pandemic, p = 0.014). Among mothers with infants younger than 5 months who had a delivery during the pandemic (n = 189), only 37.0% (n = 70) reported exclusively breastfeeding during the 24 h before completing the survey. Multiple logistic regression analysis indicated that receiving support for all five steps was positively associated with exclusive breastfeeding during the 24 h before the survey (adjusted odds ratio 4.51; 95% CI [1.50–13.61]). Receipt of a free formula sample or invitation to a free sample campaign was negatively associated with exclusive breastfeeding (adjusted odds ratio 0.43; 95% CI [0.19–0.98]). Other factors related to non-exclusive breastfeeding were older maternal age, lower education level, primiparity, and no breastfeeding intention. Conclusions The pandemic weakened breastfeeding support for healthy women in Japan; however, support practice that adhered to WHO recommendations appeared to be effective during the pandemic.

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Threatened abortion, threatened premature labor, and preterm birth during the first state of emergency for COVID‐19 in 2020 in Japan

Cited by 15 publications

References 30 publications

Amelioration of prevalence of threatened preterm labor during the COVID-19 pandemic: nationwide database analysis in Japan

Amelioration of prevalence of threatened preterm labor during the COVID-19 pandemic: nationwide database analysis in Japan

Maternal heated tobacco product use during pregnancy and allergy in offspring

Influence of the COVID-19 pandemic on breastfeeding support for healthy mothers and the association between compliance with WHO recommendations for breastfeeding support and exclusive breastfeeding in Japan

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