Threats and Interventions During the Treatment of Tuberculosis in an Inner-city District

Jove, Neus; Masdeu, Eva; Brugueras, Sílvia; Millet, Joan-Pau; Ospina, Jesús E.; Orcau, Àngels; Rius, Cristina; Caylà, Joan A.; Sánchez, Francesca

doi:10.1016/j.arbr.2020.05.016

Cited by 2 publications

(2 citation statements)

References 18 publications

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“…For Gamma-GT, the reference values for men are from 07 to 60 U/L and for women it is from 05 to 43 U/L. For alkaline phosphatase, the reference values are: men from 40 to 129 U/L and for women from 35 to 104 U/L (Jové et al, 2021)…”

Section: Determination Of Liver Functionsmentioning

confidence: 99%

“…The pharmacological use of levofloxacin, a thirdgeneration quinolone, can cause several adverse reactions during treatment, such as hepatotoxicity, which usually manifests itself in a few cases, however, severe cases are potentially fatal. Risk factors associated with levofloxacin hepatotoxicity are genetic predisposition, age, nutritional status, comorbidities and concomitant exposure to other hepatotoxic agents (Babalik et al, 2013;Jové et al, 2021).…”

Section: Catalase-cat Dosagementioning

confidence: 99%

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Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

Sales,

Pinto-Silva,

Bardález-Rivera

et al. 2023

Braz. J. Biol.

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This study aimed to correlate the values of liver markers with oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon. A total of 30 patients from the Tuberculosis clinic of a referral hospital were admitted to the study. Whole blood samples were collected for analysis of liver enzyme values and oxidative stress markers by spectrophotometry. The prevalence was male (60%) and the 18-29 age group was the most affected. Patients with multidrug-resistant tuberculosis presented catalase values with a median equal to 6.94 U/gHb and for glutathione, the median was equal to 14.76 µg∕ml. As for the values of liver enzymes (AST, ALT, Gamma-GT and Alkaline phosphatase) the patients had medians equal to 60.50 (U/L); 80 (U/L); 54 (U/L); and 100 (U/L) respectively (p<0.0001). The results suggest a hepatotoxic effect of the drug, which recommends further studies with a larger number of samples in order to investigate the predictors of liver damage in patients with multidrug-resistant tuberculosis.

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Section: Determination Of Liver Functionsmentioning

confidence: 99%

Section: Catalase-cat Dosagementioning

confidence: 99%

Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

Sales,

Pinto-Silva,

Bardález-Rivera

et al. 2023

Braz. J. Biol.

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Clinical characteristics and distinguishing factors of patients with COVID-19 complicated with active pulmonary tuberculosis

Ma,

2024

Journal of Investigative Medicine

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The current study was conducted aimed at exploring the clinical characteristics and distinguishing factors of patients with the novel coronavirus pneumonia (COVID-19) complicated with active pulmonary tuberculosis. A total of 354 patients with COVID-19 in our hospital from November 2022 to February 2023 were included in the present study, of whom 87 patients were also combined with active pulmonary tuberculosis. Significant differences were found in fever, fatigue, nasal congestion, nasal discharge, sore throat, expectoration and weight loss between the two groups (P<0.05). There were significant differences in the levels of leukocyte, neutrophil, lymphocyte count, monocyte, hemoglobin, C-reactive protein and CD4/CD8 between the two groups (P<0.05). There were significant differences in pulmonary consolidation, multifocal ground-glass opacities in both lungs, and infiltrating shadows, “cavity” by CT imaging between the two groups (P<0.05). The independent variables were set as the indicators with different results of clinical characteristics and CT imaging, including fever, fatigue, nasal congestion, nasal discharge, sore throat, expectoration, weight loss, leukocytes, count neutrophils and lymphocytes, monocytes, hemoglobin, C-reactive protein, CD4/CD8, pulmonary consolidation, multifocal ground-glass opacities in both lungs and infiltration shadows. Our findings have revealed that fever, fatigue, expectoration, leukocytes, neutrophils, monocytes, hemoglobin, C-reactive protein, lymphocytes, CD4/CD8, pulmonary consolidation, multifocal ground-glass opacities in both lungs, and infiltration shadows were the risk factors responsible for the patients with COVID-19 complicated with active pulmonary tuberculosis.

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Threats and Interventions During the Treatment of Tuberculosis in an Inner-city District

Cited by 2 publications

References 18 publications

Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

Level function levels and oxidative stress markers in patients with multidrug-resistant tuberculosis in the Brazilian Amazon

Clinical characteristics and distinguishing factors of patients with COVID-19 complicated with active pulmonary tuberculosis

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