Three anticancer Pt complexes with glycine derivatives: synthesis, bioactivity on MCF-7 cell line, ADME prediction, DFT, MEP, and molecular docking

Moghadam, Mahboube Eslami; Jafari, Ameneh; Khashandaragh, Ramin Kiani; Divsalar, Adeleh; Ghasemzadeh, Mitra

doi:10.1007/s13738-021-02154-7

Cited by 11 publications

(2 citation statements)

References 30 publications

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“…The research revealed the interaction between the new complex and DNA. Circular dichroism (CD) spectrum confirmed the bonding of the positively charged complex through electrostatic interactions, which are less effective than hydrogen interactions, from which we can conclude that the side effects of glycine derivatives can be significantly reduced compared to cisplatin [ 26 ].…”

Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

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There is a need for new, safer, and more effective agents to treat cancer. Cytostatics that have transition metals at their core have attracted renewed interest from scientists. Researchers are attempting to use chemotherapeutics, such as cisplatin, in combination therapy (i.e., in order to enhance their effectiveness). Moreover, studies are being carried out to modify molecules, by developing them into multinuclear structures, linking different compounds to commonly used drugs, or encapsulating them in nanoparticles to improve pharmacokinetic parameters, and increase the selectivity of these drugs. Therefore, we attempted to organize recent drug findings that contain palladium and platinum atoms in their structures.

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Section: Modifications Of Platinum- and Palladium-based Moleculesmentioning

confidence: 99%

Platinum and Palladium Complexes as Promising Sources for Antitumor Treatments

Czarnomysy

Radomska

Szewczyk

et al. 2021

IJMS

View full text Add to dashboard Cite

show abstract

“…In drug discovery and development, thiourea-derived compounds have been reported to have anti-tumour [ 14 , 18 , 28 , 43 , 44 ], antibacterial, antimicrobial, and anti-tuberculosis activity [ 6 , 7 , 16 , 36 , 39 , 40 ], as well as being soluble epoxide hydrolase inhibitors and antiviral [ 8 ]. Recently, metal complexes of different transition metals (e.g., platinum, iron, ruthenium, and cobalt) have become the preferred candidates for developing treatments for other cancer types [ 1 , 11 , 15 , 22 , 23 ].…”

Section: Introductionmentioning

confidence: 99%