Three aromatic amino acids in gastric juice as potential biomarkers for gastric malignancies

Deng, Kai; Lin, Sanren; Zhou, Liya; Geng, Qiuming; Li, Yuan; Xu, Man; Na, Renhua

doi:10.1016/j.aca.2011.03.053

Cited by 39 publications

(48 citation statements)

References 28 publications

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“…This finding was further supported by Deng and colleagues (25), who showed that median concentrations of tryptophan in gastric content of patients with gastric cancer were 19.4 AE 4.7 mg/mL, compared with 2.7 AE 1.0 mg/mL in controls (P < 0.05). The second study by Deng and colleagues (26) showed that the AUC for gastric content tryptophan concentrations was 0.819 (95% CI, 0.739-0.900; P < 0.001) to discriminate gastric cancer from controls.…”

Section: Tryptophansupporting

confidence: 74%

“…Deng and colleagues (25) demonstrated that median concentrations of phenylalanine in gastric content were 54.3 AE 11. mg/mL in the gastric cancer group, compared with 8.8 AE 2.1 mg/mL in the control group (P < 0.05). In a second study by Deng and colleagues (26), the AUC using gastric content phenylalanine concentrations to discriminate EGC cases from controls was 0.831 (95% CI, 0.750-0.911; P < 0.001).…”

Section: Tyrosinementioning

confidence: 99%

“…The median concentration of tyrosine in the cancer group was 54.9 AE 11.0 mg/mL, compared with 8.7 AE 2.6 mg/mL in the control group (P < 0.05; ref. 25). Another study by the same group compared cases of early gastric cancer (EGC; n ¼ 49), advanced gastric cancer (AGC; n ¼ 66), and a control group of patients with nonneoplastic gastric disease (n ¼ 70).…”

Section: Tyrosinementioning

confidence: 99%

“…Deng and colleagues (25,26) have performed two studies to investigate levels of amino acids within gastric content. The initial study compared concentrations within gastric content of patients with gastric cancer (n ¼ 33) to a control group (n ¼ 68) using NMR and LC/MS.…”

Section: Tyrosinementioning

confidence: 99%

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Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Wiggins

Kumar

Markar

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

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Gastroesophageal cancer has a rapidly increasing incidence worldwide and reliable biomarkers are urgently required to facilitate earlier diagnosis and improve survival. The aromatic amino acids tyrosine, phenylalanine, and tryptophan represent potential biomarkers and their relation to gastroesophageal cancer will be evaluated in this review. An electronic literature search was performed to identify all published research relating to the measurement of tyrosine, phenylalanine, or tryptophan in the biofluids or tissues of patients with gastroesophageal cancer. Sixteen studies were included in this systematic review. Six studies investigated serum concentrations, which all found decreased concentrations of these aromatic amino acids, except one study that found increased phenylalanine. Five studies reported increased concentrations within gastric content of these patients and two reported increased urinary concentrations. Tissue concentrations of these aromatic amino acids were increased in three studies. Tyrosine, phenylalanine, and tryptophan represent potential biomarkers of gastroesophageal cancer, and further research is necessary to definitively establish the mechanism responsible for altered concentrations of these compounds in patients with gastroesophageal cancer. Cancer Epidemiol Biomarkers Prev; 24(1); 32-38. Ó2014 AACR.

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Section: Tryptophansupporting

confidence: 74%

Section: Tyrosinementioning

confidence: 99%

Section: Tyrosinementioning

confidence: 99%

Section: Tyrosinementioning

confidence: 99%

See 2 more Smart Citations

Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Wiggins

Kumar

Markar

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

103

View full text Add to dashboard Cite

show abstract

“…141 Furthermore, measuring the fluorescence intensity of gastric juice by mass spectra offers the possibility of detecting fluorescence biomarkers. 142 Three aromatic amino acids in gastric juice could correctly predict gastric malignancies with AUROCs of 0.838, 0.856 and 0.816 for tyrosine, phenylalanine and tryptophan, respectively. Additional work is required to clarify the reasons for the changes in the fluorescence emission spectrum, and its diagnostic performance should be further validated in future studies.…”

Section: Gastric Juicementioning

confidence: 99%

Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms

2017

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Gastrointestinal cancer is a leading contributor to cancer-related morbidity and mortality worldwide. Early diagnosis currently plays a key role in the prognosis of patients with gastrointestinal cancer. Despite the advances in endoscopy over the last decades, missing lesions, undersampling and incorrect sampling in biopsies, as well as invasion still result in a poor diagnostic rate of early gastrointestinal cancers. Accordingly, there is a pressing need to develop noninvasive methods for the early detection of gastrointestinal cancers. Biomedical optical spectroscopy, including infrared spectroscopy, Raman spectroscopy, diffuse scattering spectroscopy and autofluorescence, is capable of providing structural and chemical information about biological specimens with the advantages of non-destruction, non-invasion and reagent-free and waste-free analysis and has thus been widely investigated for the diagnosis of oesophageal, gastric and colorectal cancers. This review will introduce the advances of biomedical optical spectroscopy techniques, highlight their applications for the early detection of gastrointestinal cancers and discuss their limitations.

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Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion

2017

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Hyperacidity in the stomach is known to promote the progression of gastric cancer. The plant‐derived chemotherapeutic curcumin is used to treat gastric cancer. The objective of this study was to investigate whether curcumin regulates gastrin‐mediated acid secretion in suppressing gastric cancer. Gastric cancer cells were treated with 25 μ m curcumin, followed by Annexin V/propidium iodide double‐staining assay to evaluate cell apoptosis. Western blot analysis was used to analyze caspase‐3 expression in response to curcumin treatment. Gastrin levels in culture medium were also monitored. Mice bearing gastric cancers were treated with curcumin, followed by analysis of tumor caspase‐3 expression, gastric acid pH , and gastric secretion in serum. Curcumin prominently inhibited gastric cancer cell proliferation and promoted cell apoptosis. Caspase‐3 was upregulated by curcumin treatment. Curcumin also reduced gastrin secretion. Curcumin dramatically inhibited tumor growth, increased gastric pH , and reduced gastric secretion. In gastric cancer, curcumin suppresses gastrin‐mediated acid secretion, which inhibits gastric cancer progression.

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Three aromatic amino acids in gastric juice as potential biomarkers for gastric malignancies

Cited by 39 publications

References 28 publications

Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Tyrosine, Phenylalanine, and Tryptophan in Gastroesophageal Malignancy: A Systematic Review

Biomedical optical spectroscopy for the early diagnosis of gastrointestinal neoplasms

Curcumin suppresses gastric cancer by inhibiting gastrin‐mediated acid secretion

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