Three-band decomposition analysis in multiscale FSI models of abdominal aortic aneurysms

Abstract

Computational modeling plays an important role in biology and medicine to assess the e®ects of hemodynamic alterations in the onset and development of vascular pathologies. Synthetic analytic indices are of primary importance for a reliable and e®ective a priori identi¯cation of the risk. In this scenario, we propose a multiscale°uid-structure interaction (FSI) modeling approach of hemodynamic°ows, extending the recently introduced three-band decomposition (TBD) analysis for moving domains. A quantitative comparison is performed with respect to the most common hemodynamic risk indicators in a systematic manner. We demonstrate the reliability of the TBD methodology also for deformable domains by assuming a hyperelastic formulation of the arterial wall and a Newtonian approximation of the blood°ow. Numerical simulations are performed for physiologic and pathologic axially symmetric geometry models with particular attention to abdominal aortic aneurysms (AAAs). Risk assessment, limitations and perspectives are¯nally discussed.

Multi-band decomposition analysis: application to cardiac alternans as a function of temperature

“…The rationale is the important link between the MBDA technique and the notion of wall shear stress gradient (WSSG). In particular, the WSSG is implicitly defined as a spatiotemporal quantity related with the fluid motion (Cherubini et al 2015) and the generalized MBDA technique has been shown to gain much information with respect to the usual synthetic indicators (Nestola et al 2015(Nestola et al , 2016. On these bases, in the context of cardiac dynamics, which is analogously a spatiotemporal problem, we foresee the application of an extended MBDA for the definition of novel clinical synthetic risk indicators for the predictive identification of pathological situations eventually evolving into sudden cardiac death.…”

Simulation Analysis of Blood Flow in Arteries of the Human Arm

“…Al-Rawi and Al-Jumaily 10 studied abdominal aorta narrowing using computational fluid dynamics and found that arterial blockage in excess of 20% of the diameter significantly influences the pressure wave and reduces the systolic blood pressure at the right femoral artery. Nestola et al 11 performed simulation for abdominal aortic aneurysms, bringing attention to three-band decomposition methodology for analysis of moving domains. The importance of shunt angulations as a determinant of shear-stress-induced thrombosis was proposed by Celestin et al, 12 who analyzed characteristics of blood flow from central aorta to pulmonary artery.…”

Comparison of existing aneurysm models and their path forward

“…Most research on CAs based on the FSI approach focuses on the calculation of WSS, while specific statements on circumferential wall stress are omitted or discussed secondary [144][145][146]. The same observation can be made for research on early AAA development [147]. In both, solid structure computation is primarily used to simulate the influence of wall deformation on the fluid and therefore supersede the boundary condition of a rigid wall.…”