Three Cases of Adenomyoepithelioma: An Unusual Breast Neoplasm

Abstract

Adenomyoepithelioma of the breast is an unusual tumor characterized by biphasic proliferation of both epithelial and myoepithelial cells. Although most of these tumors have a benign course, a small number of malignant lesions have been reported in the literature. Adenomyoepithelioma is also characterized by propensity for local recurrence. Therefore , the sufficiency of initial surgery plays very important role in the management of these tumors. Due to the potential to malignant transformation and high risk of local recurrence, totally excision with wide margins should be performed in surgical treatment of these tumors. In this paper, three cases of adenomyoepithelioma of the breast with different clinical presentations and radiological findings were reported. J Clin Exp Invest 2016; 7 (1): 91-93

Malignant adenomyoepithelioma of the breast: A rare case report

“…This transformation is indicated by features such as prominent cytological atypia, high mitotic activity, necrosis, and an infiltrative growth pattern [6,7,9]. Generally, only one cellular component (epithelial or myoepithelial) becomes malignant, whereas the presence of malignant changes in both cell types is an extremely rare occurrence [10,11].…”