Three Cases of an Unusual Pattern of Invasion in Malignant Brenner Tumors

Abstract

Ovarian malignant Brenner tumors are rare neoplasms that are typically admixed with benign and borderline Brenner tumor elements. We report 3 cases of an unusual variant of malignant Brenner tumor where the infiltrative malignant component arose directly from a benign Brenner tumor rather than from borderline elements and did not exhibit a desmoplastic stromal response. Borderline elements were present in 1 case, but the invasive component did not arise from these. Our cases highlight that an absence of a borderline element should not dissuade the pathologist from diagnosing a malignant Brenner tumor.

Ovarian Low-grade Basaloid Carcinoma Arising in Brenner Tumor: A New Variant of Malignant Brenner Tumor

“…They are defined by the presence of stromal invasion which can be confluent with stromal exclusion or more uncommonly infiltrative/destructive in nature. They usually arise from a borderline Brenner tumor, although rarely the invasive component arises directly from a benign Brenner tumor with no borderline component (6). These "usual" MBTs have a completely different morphology to the cases we report.…”

Malignant Brenner Tumor of the Ovary: A Systematic Review of the Literature

“…The publication years ranged from 1956 to 2023. The age in 108/115 (93.9%) cases [ 2 , 8 , 9 , 10 , 11 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ] was reported. Specifically, the mean age at presentation was 59 ± 13 years, ranging from 22 to 87 years.…”

“…Specifically, the mean age at presentation was 59 ± 13 years, ranging from 22 to 87 years. Presenting symptoms were reported in 113/115 (98.3%) patients [ 2 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. The most common presenting symptom was abdominal pain, which was present in 42/113 patients (37.1%) [ 2 , 13 , 19 , 22 , 26 , 27 , …”

“…Data concerning laterality were provided in 97/115 (84.3%) cases [ 2 , 8 , 9 , 10 , 11 , 12 , 14 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 42 , 43 , 44 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]; 45/97 (46.4%) cases involved the right ovary [ 2 , 9 , 16 , 17 , 18 , 21 , 24 , 25 , 26 , 29 , 30 , …”

“…Histologically, MBTs are composed of atypical transitional/urothelial-type cells that occasionally display focal squamous differentiation. By definition, they show stromal invasion, usually with a desmoplastic stromal response, and are associated with a benign and/or borderline element [ 8 ].…”