Three cases of giant pilomatrixoma – considerations for diagnosis and treatment of giant skin tumours with abundant inner calcification present on the upper body

Yamauchi, M.; Yotsuyanagi, Takatoshi; Saito, Tomoya; Ikeda, Kimiyuki; Urushidate, Satoshi; Higuma, Yuko

doi:10.1016/j.bjps.2009.12.006

Cited by 30 publications

(27 citation statements)

References 26 publications

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“…6 In the case reported here, the option was the surgical excision of the tumor, assuring safety margins, due to diagnostic uncertainty and history of lesion recurrence, which is consistent with the literature. 6,12 The diameter of the lesion is not correlated with the prognosis. Recurrences may be related to incomplete resections, 11 as probably occurred in the case described here.…”

Section: Cells With Shadows Of Lost Nuclei and Clear Intercellular LImentioning

confidence: 99%

“…It was considered the differential diagnoses of epidermoid cyst, sarcoma, calcified hemangioma, giant dermatofibroma, cutaneous lymphoma, cutaneous metastasis and basal cell carcinoma. 12 Often, imaging studies are used to assist in the diagnosis, such as computerized tomography, in which GPM appears as well-defined calcified masses separated from the subcutaneous cellular tissue by a layer of fat. Fine-needle aspiration biopsy is helpful in the diagnosis; however, the nuclear atypia seen in squamous cells and the misinterpretation of basaloid cells as malignant made the following diagnostic confusion: PM as squamous cell carcinoma, basal cell carcinoma, pleomorphic adenoma with squamous metaplasia, cutaneous and metastatic neuroendocrine carcinoma, salivary gland tumors and other tumors of skin appendages.…”

Section: Cells With Shadows Of Lost Nuclei and Clear Intercellular LImentioning

confidence: 99%

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An unusual presentation of giant pilomatrixoma in an adult patient

Souto

Matsushita²,

Matsushita³

et al. 2013

J Dermatol Case Rep

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Background: Pilomatrixoma (OMIM ID #132600) is a benign cutaneous tumor originating from the pilosebaceous follicle and characterized by the presence of subcutaneous nodules of up to 3.0 cm in diameter, usually on the head, neck and upper extremities. It is most common in the first two decades of life and after the age of 60.Main observations: An adult female patient was evaluated, presenting a solid tumoral lesion with erythematous surface and purplish tone, with approximately 7.5 x 5.0 cm in size, in the interscapulovertebral region. It was thought to be an epidermoid cyst, sarcoma, calcified hemangioma, giant dermatofibroma, or nodular basal cell carcinoma. The resection of the lesion was carried out and, at the histological examination, specific details were observed that led to the diagnosis of pilomatrixoma. Conclusion:Pilomatrixoma should be suspected in the differential diagnosis of giant adnexal tumors. (J Dermatol Case Rep. 2013; 7(2): 56-59) An unusual presentation of giant pilomatrixoma in an adult patient IntroductionPilomatrixoma (PM; OMIM ID #132600) was first described in 1880 by Malherbe and Chenatais as a "calcified epithelioma of Malherbe" originated from sebaceous glands. In 1961, Forbis and Helwig demonstrated that the tumor originated from the hair matrix; therefore, the name pilomatrixoma. 1-3 PM is the most common hair-follicle tumor and it accounts for one of every 500 specimens submitted by dermatologists. 4 Clinically, the lesion is a benign cutaneous tumor usually characterized by a solitary asymptomatic, firm, and skin-colored faint blue/red nodule in the deep dermis and subcutaneous tissue, with an average size of 0.5 to 3.0 cm. The lesions larger than 5.0 cm are defined as giant pilomatrixomas. Pain and tenderness may be associated symptoms. 3,5 The tumor is generally observed on the head, neck and upper extremities. 6 It is a common skin neoplasm in the pediatric population, but it may be found in all age groups with bimodal peaks under the age of 30 and in the sixth/seventh decades of life. 5,6 Uncommon clinical-pathological variants of PM have been reported, such as bullous like, anetodermic, exophytic, perforating/ulcerated and lymphagiectatic. Multiple and familial cases have been described in association with myotonic dystrophy, Turner's syndrome, Gardner's syndrome, xeroderma pigmentosum, basal cell nevus syndrome and Sotos syndrome. 6,7 The present paper reports an unusual and uncommon case of pilomatrixoma on the back of an adult female patient. Case ReportA 54-year-old female patient sought the medical specialties outpatient service at School of Medical Sciences at Universidade de Marília (UNIMAR) complaining about a back injury three years ago, with progressive growth and sporadic local pain. The patient had undergone a surgery for the removal of the lesion in another hospital two and a half years before, but there was local recurrence 3 months after surgery. Krausen et al. 9 described the first case of giant PM (GPM), few similar lesions were described 5 a...

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Section: Cells With Shadows Of Lost Nuclei and Clear Intercellular LImentioning

confidence: 99%

Section: Cells With Shadows Of Lost Nuclei and Clear Intercellular LImentioning

confidence: 99%

An unusual presentation of giant pilomatrixoma in an adult patient

Souto

Matsushita²,

Matsushita³

et al. 2013

J Dermatol Case Rep

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“…Recent investigations have shown that recurrent mutations in the beta-catenin gene are responsible (1). It has been reported to be related with myotronic dystrophy gene, polyoma virus, Gardner syndrome, xeroderma pigmentosum, Turner syndrome, sarcoidosis and basal cell nevus syndrome (1,12). No sign which might be related with these conditions was found in our patients.…”

Section: Discussionmentioning

confidence: 41%

Pilomatrixoma localized in the arm and forearm

Dabak¹,

Çıraklı²,

Kandemır³

et al. 2015

Turk Arch Ped

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Pilomatrixoma is a rare benign skin tumor arising from hair follicle stem cells which is also known as calcifying epithelioma of Malharbe. It occurs with a rate of 0.1% among skin tumors. The definite diagnosis is made histopathologically. In treatment, it is recommended that the lesion be excised surgically. In this study, we wished to present two patients who presented with swelling and underwent excisional biopsy as a result of magnetic resonance imaging and whose pathological result was reported to be pilomatrixoma in accompaniment with the literature. (Türk Ped Arş 2014; 49: 340-3)

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“…It has been reported to be related with myotronic dystrophy gene, polyoma virus, Gardner syndrome, xeroderma pigmentosum, Turner syndrome, sarcoidosis and basal cell nevus syndrome [1,11,12]. No sign which might be related with these conditions was found in our patients.…”

Section: Open Accessmentioning

confidence: 39%

Giant Pilomatricoma of the Scalp: A Case Report

Chakiri¹,

Gallouj²,

Rimani³

2017

IJCDR

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Pilomatricoma is a benign cutaneous tumor originating from hair follicle matrix cells and characterized by the presence of subcutaneous nodules of up to 3.0 cm in diameter, usually on the head, neck and upper extremities. It is most common in the first two decades of life and after the age of 60. We report a case of an adult female patient was evaluated, presenting a solid tumoral lesion, with approximately 3.5 x 3.0 cm in size, in the scalp. It was thought to be a squamous cell carcinoma, sarcoma, amelanotic melanoma, or nodular basal cell carcinoma. The resection of the lesion was carried out and, at the histological examination, specific details were observed that led to the diagnosis of pilomatricoma. Pilomatricoma should be suspected in the differential diagnosis of other cutaneous tumors.

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Three cases of giant pilomatrixoma – considerations for diagnosis and treatment of giant skin tumours with abundant inner calcification present on the upper body

Cited by 30 publications

References 26 publications

An unusual presentation of giant pilomatrixoma in an adult patient

An unusual presentation of giant pilomatrixoma in an adult patient

Pilomatrixoma localized in the arm and forearm

Giant Pilomatricoma of the Scalp: A Case Report

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