Three cases of pancreatic serous cystadenoma and endocrine tumour

Blandamura, Stella; Parenti, Anna; Famengo, Barbara; Canesso, Alessandra; Moschino, P; Pasquali, Claudio; Pizzi, Sara; Guzzardo, Vincenza; Ninfo, Vito

doi:10.1136/jcp.2006.036954

Cited by 37 publications

(27 citation statements)

References 29 publications

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“…As with clear cell endocrine tumors of the pancreas, these lesions are also seen in association with von Hippel-Lindau disease, and they may coexist with pancreatic endocrine neoplasms [14]. …”

Section: Discussionmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma to the Pancreas: Diagnostic Significance of Fine-Needle Aspiration Cytology

Gilani¹,

Tashjian²,

Danforth³

et al. 2013

Acta Cytologica

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Background: Renal cell carcinoma rarely metastasizes to the pancreas. Diagnosing a neoplasm that is metastatic to the pancreas by fine-needle aspiration (FNA) cytology is often challenging. A detailed clinical history may prove to be beneficial. Case Reports: A total of 729 pancreatic FNAs were performed from January 2005 through August 2012 at our institution. Among these, we found 3 patients with a prior history of a malignant renal neoplasm who presented with a pancreatic mass: 2 in the tail and 1 in the head. Radiographically, they ranged in size from 2.5 to 7.0 cm. Microscopic evaluation of cytologic material obtained during endoscopic ultrasound-guided FNA (EUS-FNA) revealed cohesive clusters of atypical cells with clear cytoplasm and prominent nucleoli surrounded by a thin capillary network. The neoplastic cells were immunoreactive with CD10 (cases 2 and 3). A diagnosis of metastatic clear cell renal cell carcinoma was rendered for each case based on the morphologic features and immunohistochemical staining pattern of the neoplastic cells. Histologic comparison with the available slides of the corresponding primary renal neoplasm confirmed the diagnosis. Conclusion: We conclude that EUS-FNA of pancreatic masses is an important, effective, and accurate diagnostic modality for early diagnosis of both primary and metastatic neoplasms of the pancreas.

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Section: Discussionmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma to the Pancreas: Diagnostic Significance of Fine-Needle Aspiration Cytology

Gilani¹,

Tashjian²,

Danforth³

et al. 2013

Acta Cytologica

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“…Neuroendocrine tumours are the most reported histological type to coexist with SCNs [7] Notably, 20% of cases of combined SCN and neuroendocrine tumours were related to VHL disease [8]. It has been hypothesised that SCNs and neuroendocrine tumours are derived from a common ductular/centroacinar origin [8].…”

Section: Discussionmentioning

confidence: 99%

A Serous Cystic Neoplasm of the Pancreas Coexisting with High-Grade Pancreatic Intraepithelial Neoplasia Mimicking an Intraepithelial Papillary Mucinous Neoplasm: A Case Report

et al. 2017

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Serous cystic neoplasms of the pancreas are rare exocrine pancreatic neoplasms, most of which are benign and do not communicate with the pancreatic duct. Pancreatic intraepithelial neoplasm (PanIN) is considered a precursor of ductal adenocarcinoma that is microscopically recognized in pancreatic ducts. A 67-year-old Japanese woman presented with a 10-mm multilocular cystic lesion at the pancreatic body. Magnetic resonance pancreatography showed stenosis of the main pancreatic duct at the pancreatic body and dilatation of the distal side of the main pancreatic duct. Furthermore, communication between the cystic lesion and the main pancreatic duct was suspected based on magnetic resonance pancreatography findings. Distal pancreatectomy was performed under the preoperative diagnosis of intraductal papillary mucinous neoplasm. Histologically, the cystic lesion was lined with a non-atypical cuboidal or flat epithelium with clear cytoplasm and was thus diagnosed as a serous cystic neoplasm. High-grade PanIN lesions with stromal fibrosis were observed at the main and branch pancreatic ducts. Histological examination revealed no communication between the serous cystic neoplasm and the pancreatic ducts. Immunohistochemically, the epithelium of the serous cystic neoplasm showed positive anti-von Hippel-Lindau antibody staining, whereas the epithelium of the PanIN showed negative staining. A serous cystic neoplasm coexisting with another pancreatic neoplasm is rare. When dilatation of the main or branch pancreatic ducts coexists with a serous cystic neoplasm, as in this case, the lesion clinically mimics an intraductal papillary mucinous neoplasm.

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“…There are twelve reports of VHL disease complicated by obstructive jaundice in the literature (20)(21)(22)(23)(24)(25)(26)(27)(28). Pancreatectomy was performed in three patient, a biliary bypass was performed in one patient with a cystoadenoma, and endoscopic management with biliary stent placement was performed in one patient who had a simple cyst compressing the common bile duct.…”

Section: Discussionmentioning

confidence: 99%

Imaging Findings of Pancreatic Cystic Lesions in von Hippel-Lindau Disease

et al. 2012

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Objectives The aim of this study was to characterize the pancreatic cystic lesions in von Hippel-Lindau (VHL) disease and to document the changes that occur in the pancreas. Methods We retrospectively analyzed the medical records and the computed tomography (CT) and magnetic resonance imaging (MRI) findings of 20 VHL patients who were diagnosed between 1996 and 2010 at our hospital. The clinical findings, family history and type of tumors and/or cysts were reviewed for each patient. We also analyzed the imaging findings for the pancreas in detail. Results Pancreatic involvement was noted in 16 of the 20 patients (80%). Eleven patients had multiple cysts diffusely distributed in the pancreas, and one patient had a single cyst in the pancreas head. Two patients had serous cystic neoplasms (SCNs) with multiple cysts, and another two patients had neuroendocrine tumors (NETs) which were conventional radiological findings. The largest cysts of four patients (26.7%) increased in size and that of three patients (20%) decreased in size during the follow-up period. We performed surgical resections for the pancreatic tumors (one NET and one SCN) and also performed endoscopic treatment for a pancreatic cyst in one VHL patient with obstructive jaundice. None of the patients died as a result of pancreatic disease. Conclusion The most common type of pancreatic lesions was multiple cysts. SCNs were present in only 10% of the VHL patients. Pancreatic cysts showed positive and/or negative growth according to the CT and MRI findings. The pancreatic cystic lesions did not influence the outcome of the VHL patients.

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Three cases of pancreatic serous cystadenoma and endocrine tumour

Cited by 37 publications

References 29 publications

Metastatic Renal Cell Carcinoma to the Pancreas: Diagnostic Significance of Fine-Needle Aspiration Cytology

Metastatic Renal Cell Carcinoma to the Pancreas: Diagnostic Significance of Fine-Needle Aspiration Cytology

A Serous Cystic Neoplasm of the Pancreas Coexisting with High-Grade Pancreatic Intraepithelial Neoplasia Mimicking an Intraepithelial Papillary Mucinous Neoplasm: A Case Report

Imaging Findings of Pancreatic Cystic Lesions in von Hippel-Lindau Disease

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