Three cases of paralytic poliomyelitis associated with type 3 vaccine poliovirus strains in Bulgaria

Korsun, Neli; Kojouharova, Mira; Vladimirova, Nadezhda; Fiore, Lucia; Litvinenko, I. V.; Buttinelli, Gabriele; Fiore, Stefano; Voynova-Georgieva, Violeta; Mladenova, Z.; Georgieva, Daniela

doi:10.1002/jmv.21545

Cited by 6 publications

(3 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, for all diseases except polio, reports of single, unlinked cases of disease were excluded. Polio has been absent from the European region since 2002 (22, 23), therefore a single case would be considered an outbreak and included. Data not disaggregated into distinct outbreaks were included in the narrative synthesis but excluded from spatial mapping.…”

Section: Methodsmentioning

confidence: 99%

Migration and Outbreaks of Vaccine-Preventable Disease in Europe: A Systematic Review

Deal

Halliday

Crawshaw

et al. 2021

Preprint

View full text Add to dashboard Cite

BackgroundMigrant populations (defined as foreign-born) are one of several under-immunised groups in the EU/EEA, yet little is known about how they are affected by outbreaks of vaccine-preventable diseases (VPDs). This information is vital to develop targeted strategies to improve the health of diverse migrant communities and to assess risk factors and correlations with major European peaks in incidence of key VPDs over time.MethodsWe did a systematic review (PROSPERO CRD42019157473; Medline, EMBASE, and Global Health January 2000 to October 2019) adhering to PRISMA guidelines, to identify studies on VPD outbreaks (measles, mumps, rubella, diphtheria, pertussis, polio, hepatitis A, N meningitidis, and H influenzae) in migrants residing in the EU/EEA and Switzerland.Results45 studies were included, reporting on 47 distinct VPD outbreaks across 13 countries (26 [55%] were reported between 2010 and 2020, including 16 [34%] since 2015). Most reported outbreaks involving migrants were of measles (n=24; 6578 total cases), followed by varicella (n=11; 596 cases), hepatitis A (n=7; 1510 cases), rubella (n=3; 487 cases) and mumps (n=2; 295 cases). 19 (40%) of outbreaks, predominantly varicella and measles, were reported in temporary camps or shelters for asylum seekers and refugees. Of 11 varicella outbreaks, 82% were associated with adult migrants. Half of measles outbreaks (n=12) were associated with migrants from Eastern European countries, often involving migrants of Roma ethnicity.ConclusionsMigrants represent one of several under-immunised groups involved in VPD outbreaks in Europe, with adult and child refugees and asylum seekers residing in shelters or temporary camps at particular risk, alongside specific nationality groups. Vulnerability varies by disease, setting, and individual demographics, highlighting the importance of tailoring strategies for implementing catch-up vaccination to specific groups, alongside the strengthening of routine data collection, in order to meet regional and global vaccination targets. Better understanding vaccine uptake and demand issues in migrant groups, and reducing the barriers they face to accessing vaccination services, is urgently needed, with direct implications for COVID-19 vaccine delivery at the current time. Strengthening vaccine delivery to migrant populations will require a greater focus on co-designing vaccine uptake strategies in close collaboration with affected communities.FunderNIHR

show abstract

Section: Methodsmentioning

confidence: 99%

Migration and Outbreaks of Vaccine-Preventable Disease in Europe: A Systematic Review

Deal

Halliday

Crawshaw

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…Guillain-Barré syndrome is a rare disorder in which a person’s own immune system damages the nerve cells, causing muscle weakness and sometimes paralysis. This group also includes 5 other vaccines associated with nervous system disorders, including pertussis vaccine [26], diphtheria and tetanus toxoids and pertussis (DTP) vaccine [27], hepatitis B vaccine [28], chickenpox vaccine [29], and poliovirus vaccine [30,31]. As shown by a VO hierarchical structure layout (Figure 3), these 7 vaccines belong to different bacterial and viral vaccine groups.…”

Section: Resultsmentioning

confidence: 99%

Network-based analysis of vaccine-related associations reveals consistent knowledge with the vaccine ontology

Zhang

Tao

et al. 2013

J Biomed Sem

View full text Add to dashboard Cite

BackgroundOntologies are useful in many branches of biomedical research. For instance, in the vaccine domain, the community-based Vaccine Ontology (VO) has been widely used to promote vaccine data standardization, integration, and computer-assisted reasoning. However, a major challenge in the VO has been to construct ontologies of vaccine functions, given incomplete vaccine knowledge and inconsistencies in how this knowledge is manually curated.ResultsIn this study, we show that network-based analysis of vaccine-related networks can identify underlying structural information consistent with that captured by the VO, and commonalities in the vaccine adverse events for vaccines and for diseases to produce new hypotheses about pathomechanisms involving the vaccine and the disease status. First, a vaccine-vaccine network was inferred by applying a bipartite network projection strategy to the vaccine-disease network extracted from the Semantic MEDLINE database. In total, 76 vaccines and 573 relationships were identified to construct the vaccine network. The shortest paths between all pairs of vaccines were calculated within the vaccine network. The correlation between the shortest paths of vaccine pairs and their semantic similarities in the VO was then investigated. Second, a vaccine-gene network was also constructed. In this network, 4 genes were identified as hubs interacting with at least 3 vaccines, and 4 vaccines were identified as hubs associated with at least 3 genes. These findings correlate with existing knowledge and provide new hypotheses in the fundamental interaction mechanisms involving vaccines, diseases, and genes.ConclusionsIn this study, we demonstrated that a combinatorial analysis using a literature knowledgebase, semantic technology, and ontology is able to reveal important unidentified knowledge critical to biomedical research and public health and to generate testable hypotheses for future experimental verification. As the associations from Semantic MEDLINE remain incomplete, we expect to extend this work by (1) integrating additional association databases to complement Semantic MEDLINE knowledge, (2) extending the neighbor genes of vaccine-associated genes, and (3) assigning confidence weights to different types of associations or associations from different sources.

show abstract

“…Therefore, for all diseases except polio, reports of single, unlinked cases of disease were excluded. Polio has been absent from the European region since 2002 (24,25), therefore a single case would be considered an outbreak and included. Data not disaggregated into distinct outbreaks were included in the narrative synthesis but excluded from spatial mapping.…”

Section: Search Strategy and Selection Criteriamentioning

confidence: 99%

Migration and outbreaks of vaccine-preventable disease in Europe: a systematic review

Deal

Halliday

Crawshaw

et al. 2021

The Lancet Infectious Diseases

View full text Add to dashboard Cite

Three cases of paralytic poliomyelitis associated with type 3 vaccine poliovirus strains in Bulgaria

Cited by 6 publications

References 23 publications

Migration and Outbreaks of Vaccine-Preventable Disease in Europe: A Systematic Review

Migration and Outbreaks of Vaccine-Preventable Disease in Europe: A Systematic Review

Network-based analysis of vaccine-related associations reveals consistent knowledge with the vaccine ontology

Migration and outbreaks of vaccine-preventable disease in Europe: a systematic review

Contact Info

Product

Resources

About