Three - (-) Catechin-O-Rhamnosides from the Eastern Nigeria Mistletoe with Potent Immunostimulatory and Antioxidant Activities

Ogechukwu, Omeje Edwin; Ogoamaka, Osadebe Patience; Kawamura, Akira; Hassan, Amal I.; Debbab, Abdessamad; Okechukwu, Esimone Charles; Nworu, Chukwuemeka S.; Ngozi, Nwodo; Peter, Procksh

doi:10.4172/2167-7956.1000102

Cited by 4 publications

(5 citation statements)

References 15 publications

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“…Mistletoe leaf meal reduce serum lipid oxidation in laying pullets at 30.56%, 43.05 and 44.31% at 1%,2% and 3% supplementation, respectively. This is in line with the report of Ogechukwu et al (2012) that antioxidants from dietary sources also play important role in the control of oxidative stress, thus limiting cellular damage. Also mistletoe alkali (a component of mistletoe) acts as inhibitor of lipid peroxidation in rats (Shi et al, 2006).…”

Section: Lipid Peroxidationsupporting

confidence: 92%

“…This shows that mistletoe endogenous antioxidant had enhancive effect on laying pullets' total antioxidant activity in a dose dependent manner. This is in line with the claims of Ogechukwu et al (2012) that antioxidation is one of the mechanism of action of mistletoe. This could be by stimulating the animal's enzymatic antioxidant system (GPx, SOD, Catalase) or non-enzymatic antioxidants (mistletoe alkali) present in mistletoe.…”

Section: Total Antioxidant Activitysupporting

confidence: 92%

“…Immune system is intricately interwoven with oxidative processes in the body. High oxidative stress usually breaks down immune system, precipitates radicals as well as severe diseases and this must be prevented (Ogechukwu et al, 2012). Even though, the body has developed a variety of ways to deal with damaging free radicals, antioxidants from dietary sources also play important role in their control, thus limiting cellular damage (Ogechukwu et al, 2012).The result obtained in this study revealed that dietary mistletoe supplement stimulates antioxidant activity and scavenge peroxide formation up to 8 weeks of lay and laying pullets have better antioxidant defense at 16 weeks of lay.…”

Section: Glutathione Peroxidasementioning

confidence: 99%

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Efecto antioxidativo de las dietas suplementadas de las comidas de hoja de mantequilla en las pulletas de colocación

Jimoh

Ihejirika

Balogun³

et al. 2018

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The present study was conducted to examine the antioxidant potential of African mistletoe (Viscum album L.) as alternative feed additive for Laying Pullets. Fresh African mistletoe leaves were harvested from cocoa trees and shade dried to constant weight. The leaves were grounded and were designated as mistletoe leaf meal (AMLM). Total of sixty ISA Brown pullets at 18 weeks old were randomly allocated to four dietary treatment consisting of 5 replicates with 3 birds per replicate, when egg production was 4% in a completely randomized design. The birds were fed layer ration and dietary mistletoe supplement as treatments T1 (basal diet + 0% AMLM), T2 (basal diet + 2% AMLM), T3 (basal diet + 4%AMLM) and T4 (basal diet + 6%AMLM) during 16 week feeding trial. At 8th week and end of the feeding trial, blood samples were collected through the Jugular vein into a sample bottle from all birds for serum oxidative indicator assay; malondialdehyde (mMDA/mgprotein), total antioxidant activity (mmol/litre), glutathione peroxidase (GPx, µgGSH/ min/mgprotein), superoxide dismutase (SOD, U/min/mg protein) and catalase (nmH2O2/min/ mg protein) using standard procedures. The result obtained revealed that at 8 weeks of lay, lipid peroxidation in laying pullets were significantly (P<0.05) lowered by mistletoe supplementation while total antioxidant activity of significantly (P<0.05) increased with mistletoe inclusion. Pullets fed 6% mistletoe supplemented diets significantly (P<0.05) enhanced catalase and glutathione peroxidase activity. Total antioxidant activity and all antioxidant enzymes of laying pullets increased, as laying cycle progresses, while lipid peroxidation reduced. This could signify that laying pullets have better antioxidative stability at 16 weeks of lay compared than pullets at 8weeks of lay. It can be concluded that African mistletoe leaf meal inclusion in laying pullets diet enhance antioxidant profile in pullets.inforMAtion Cronología del artículo. Recibido/Efecto antioxidativo de las dietas suplementadas de las comidas de hoja de mantequilla en las pulletas de colocación resUMen El presente estudio se llevó a cabo para examinar el potencial antioxidante del muérdago africano (Viscum album L.) como aditivo alimenticio alternativo para las gallinas ponedoras. Las hojas frescas del muérdago africano fueron cosechadas de los árboles del cacao y la cortina secó al peso constante. Las hojas se pusieron a tierra y se designaron como harina de muérdago (AMLM). Se asignaron aleatoriamente a un total de sesenta pollos marrones ISA a las 18 semanas de edad a cuatro tratamientos dietéticos consistentes en 5 repeticiones con 3 aves por repetición, cuando la producción de huevos fue del 4% en un diseño completamente al azar. Las aves fueron alimentadas con raciones de raciones y suplementos de muérdago dietético como tratamientos T1 (dieta basal + 0% AMLM), T2 (dieta basal + 2% AMLM), T3 (dieta basal + 4% AMLM) y T4 (dieta basal + 6% AMLM) ) durante el ensayo de alimentación de 16 semanas. A la octava semana y al final del ...

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Section: Lipid Peroxidationsupporting

confidence: 92%

Section: Total Antioxidant Activitysupporting

confidence: 92%

Section: Glutathione Peroxidasementioning

confidence: 99%

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Efecto antioxidativo de las dietas suplementadas de las comidas de hoja de mantequilla en las pulletas de colocación

Jimoh

Ihejirika

Balogun³

et al. 2018

ARCH ZOOTEC

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“…Catechin, epicatechin and derivatives were also identified. While the MIC of catechin and epicatechin are higher than 256 mg/L, it is known that epicatechin 3-O-gallate has a MIC comprised between 64 and 128 mg/L on Staphylococcus aureus strains (Agbo et al 2013;Ogechukwu et al 2012;Stapleton et al 2004). Moreover, catechin derivatives may possess, as epicatechin-3-O-gallate, the capacity to modulate blactam resistance in MRSA strains (Stapleton et al 2004;Shiota et al 1999).…”

Section: Tapinanthus Bangwensis (Engl and Krause) Danser (Loranthaceae)mentioning

confidence: 99%

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

2015

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In a world of increasing resistance to current antibiotics, search of novel therapeutic options is urgently needed. The aim of this work was to screen plant crude extracts for direct or indirect (inhibition of resistance) antimicrobial activity. Four crude extracts from 12 plants traditionally used in Africa for the treatment of infections were obtained by successive extraction with hexane, dichloromethane, ethyl acetate, and methanol. All extracts were tested against Staphylococcus aureus MRSA ATCC33591 [resistant to b-lactams by production of b-lactamases and of a modified PBP target (PBP2a)]. Direct antimicrobial activity was tested by determination of Minimal Inhibitory Concentrations (MIC), and indirect activity, by determining interactions between antibiotics and extracts using checkerboard titration and calculation of Fractional Inhibitory Concentration Index (FICI; synergy: FICI B 0.5; additivity: FICI B 1). Combined antibiotics were ampicillin (sensitive to resistance mediated by b-lactamases and PBP2a) and oxacillin (sensitive to resistance mediated by PBP2a only). The dichloromethane extract of Vitellaria paradoxa leaves, the methanol extracts of Vitellaria paradoxa, Cola gigantea leaves and twigs, and of Tapinanthus bangwensis aerial parts showed direct antimicrobial activity (MIC 250-500 mg/L). The methanol extracts of Vitellaria paradoxa and Cola gigantea leaves and twigs showed additive or synergistic effects with oxacillin and ampicillin on MRSA ATCC33591 (FICI 0.28-1), suggesting a possible inhibition of PBP2a. The methanol extract of Tapinanthus bangwensis aerial parts and Anchomanes difformis roots improved the activity of ampicillin only (FICI 0.38-1), suggesting b-lactamase inhibition. Polyphenols and particularly tannins were shown to be responsible for these last effects, at least partially for Vitellaria paradoxa. These data need further research aiming at identifying the active compounds in these extracts.

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“…Among the tested polyphenols, tutin and peltatoside in particular exhibited the most prominent radical scavenging activity [117]. Meanwhile, from the methanol extract of Loranthus micranthus leaves parasitic on host Kola acuminata , −(−) catechin-7- O -rhamnoside, −(−) catechin-3- O -rhamnoside and 4′-methoxy-catechin-7- O -rhamnoside are the most potent antioxidant polyphenols [118].…”

Section: Ethnomedicinal Usesmentioning

confidence: 99%

Parasitic Mistletoes of the Genera Scurrula and Viscum: From Bench to Bedside

et al. 2016

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Abstract:The mistletoes, stem hemiparasites of Asia and Europe, have been used as medicinal herbs for many years and possess sophisticated systems to obtain nutrients from their host plants. Although knowledge about ethnomedicinal uses of mistletoes is prevalent in Asia, systematic scientific study of these plants is still lacking, unlike its European counterparts. This review aims to evaluate the literature on Scurrula and Viscum mistletoes. Both mistletoes were found to have anticancer, antimicrobial, antioxidant and antihypertensive properties. Plants from the genus Scurrula were found to inhibit cancer growth due to presence of phytoconstituents such as quercetin and fatty acid chains. Similar to plants from the genus Viscum, Scurrula also possesses TNFα activity to strengthen the immune system to combat cancer. In line with its anticancer activity, both mistletoes are rich in antioxidants that confer protection against cancer as well as neurodegeneration. Extracts from plants of both genera showed evidence of vasodilation and thus, antihypertensive effects. Other therapeutic effects such as weight loss, postpartum and gastrointestinal healing from different plants of the genus Scurrula are documented. As the therapeutic effects of plants from Scurrula are still in exploration stage, there is currently no known clinical trial on these plants. However, there are few on-going clinical trials for Viscum album that demonstrate the functionalities of these mistletoes. Future work required for exploring the benefits of these plants and ways to develop both parasitic plants as a source of pharmacological drug are explained in this article.

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Three - (-) Catechin-O-Rhamnosides from the Eastern Nigeria Mistletoe with Potent Immunostimulatory and Antioxidant Activities

Cited by 4 publications

References 15 publications

Efecto antioxidativo de las dietas suplementadas de las comidas de hoja de mantequilla en las pulletas de colocación

Efecto antioxidativo de las dietas suplementadas de las comidas de hoja de mantequilla en las pulletas de colocación

Preliminary evidences of the direct and indirect antimicrobial activity of 12 plants used in traditional medicine in Africa

Parasitic Mistletoes of the Genera Scurrula and Viscum: From Bench to Bedside

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