2022
DOI: 10.1371/journal.pgen.1009615
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Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain

Abstract: The formation of a diploid zygote is a highly complex cellular process that is entirely controlled by maternal gene products stored in the egg cytoplasm. This highly specialized transcriptional program is tightly controlled at the chromatin level in the female germline. As an extreme case in point, the massive and specific ovarian expression of the essential thioredoxin Deadhead (DHD) is critically regulated in Drosophila by the histone demethylase Lid and its partner, the histone deacetylase complex Sin3A/Rpd… Show more

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Cited by 4 publications
(2 citation statements)
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References 66 publications
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“…Although ChIP-qPCR experiments of hand-picked genes did not reveal a correlation between increased H3K27Ac and expression levels in sin-3 mutants, stochastic effects of SIN-3 depletion on gene expression, as we observed on the X chromosome, may require single-cell approaches to address this question further. In addition, SIN-3 may play non-canonical roles in repressive chromatin ( Torres-Campana et al, 2022 ), target non-histone substrates ( Milazzo et al, 2020 ), or have functions independent of HDAC catalytic activity, including nucleosome assembly ( Chen et al, 2012 ), as suggested by the physical interaction with the NAP1 chaperone ( Moshkin et al, 2009 and our data). Some of these activities may also contribute to SIN-3-mediated gene activation.…”
Section: Discussionmentioning
confidence: 61%
“…Although ChIP-qPCR experiments of hand-picked genes did not reveal a correlation between increased H3K27Ac and expression levels in sin-3 mutants, stochastic effects of SIN-3 depletion on gene expression, as we observed on the X chromosome, may require single-cell approaches to address this question further. In addition, SIN-3 may play non-canonical roles in repressive chromatin ( Torres-Campana et al, 2022 ), target non-histone substrates ( Milazzo et al, 2020 ), or have functions independent of HDAC catalytic activity, including nucleosome assembly ( Chen et al, 2012 ), as suggested by the physical interaction with the NAP1 chaperone ( Moshkin et al, 2009 and our data). Some of these activities may also contribute to SIN-3-mediated gene activation.…”
Section: Discussionmentioning
confidence: 61%
“…Although ChIP-qPCR experiments of a number of hand-picked genes did not reveal a correlation between increased H3K27Ac and expression levels in sin-3 mutants, stochastic effects of SIN-3 depletion on gene expression, as we observed on the X, may require single cell approaches to further address this question. In addition, SIN-3 may play non-canonical roles in repressive chromatin (Torres-Campana et al, 2022), target non-histone substrates (Milazzo et al, 2020), or have functions independent of HDAC catalytic activity, including nucleosome assembly (Chen et al, 2012), as suggested by the physical interaction with the NAP1 chaperone (Moshkin et al, 2009 and our data). Some of these activities may also contribute to SIN-3 mediated gene activation.…”
Section: Discussionmentioning
confidence: 61%