This paper focuses on the disturbance rejection control problem for inertial stabilization of long-distance laser positioning with the movable platform. Due to various disturbances of the movable platform, the positioning system has significant disturbances that affect the positioning accuracy. Moreover, the nonminimum-phase property of the inertial stabilization system leads to great challenges for designing traditional disturbance-observer-based as well as rejection control methods. In this paper, a dual-compensator disturbance-observer-based control algorithm is proposed to ensure a much stronger rejection of disturbances than those of conventional methods. In particular, it is proven that the two compensators in the proposed method effectively estimate disturbances in different frequency regions. Furthermore, the analytical tuning laws for the proposed dual-compensator disturbance-observer-based control method are presented. The experimental setup including the laser positioning platform demonstrated the validity of the proposed method, which effectively rejected various disturbances.