Three-component condensation of α-nitroacetophenone, aromatic aldehydes, and methylurea

Sedova, V. F.; Krivopalov, V. P.; Shkurko, O. P.

doi:10.1007/s11172-007-0180-3

Cited by 3 publications

(1 citation statement)

References 13 publications

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“…Depending on the starting compounds, different systems of solvent/catalyst [13] and ratios of reagents [9,14,15] may be used, but heating is needed in all cases.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Acylation of 4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)- ones

Колосов

Кулык

Al‐Ogaili

et al. 2012

Zeitschrift Für Naturforschung B

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4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)-ones are useful multifunctional 3,4-dihydropyrimidine building blocks with low molecular weight and sufficient solubility, which may be modified selectively by substituents in different positions. Here we propose a simple one-pot protocol for the synthesis of these compounds, which is based on the use of common reagents viz. urea, chloroaliphatic aldehydes and 3-ketoesters. Acylation of 4-chloroalkyl-3,4-dihydropyrimidin-2(1H)-ones by carboxylic acid anhydrides leads to 3-acyl derivatives.

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“…Depending on the starting compounds, different systems of solvent/catalyst [13] and ratios of reagents [9,14,15] may be used, but heating is needed in all cases.…”

Section: Resultsmentioning

confidence: 99%

Synthesis and Acylation of 4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)- ones

Колосов

Кулык

Al‐Ogaili

et al. 2012

Zeitschrift Für Naturforschung B

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ChemInform Abstract: Three‐Component Condensation of α‐Nitroacetophenone, Aromatic Aldehydes, and Methylurea.

2008

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Noncovalent interactions in N-methylurea crystalline hydrates

Kazachenko,

Issaoui,

Holikulov

et al. 2023

Zeitschrift Für Physikalische Chemie

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Urea and its derivatives play a significant role in modern organic chemistry and find application in various fields. This study presents the results of investigations of N-methylurea crystalline hydrates. Initial N-methylurea and its crystalline hydrates have been examined by FTIR spectroscopy and X-ray diffraction analysis. It has been found that the incorporation of water molecules into N-methylurea crystals leads to a shift of intensity peaks in both the FTIR spectra and X-ray diffraction patterns. Methylurea crystalline hydrates in the gaseous phase have been additionally explored within the density functional theory at the B3LYP/6-31+G(d,p) level and the theory of atoms in molecules. The nature of water and methylurea molecular interactions via hydrogen bonds have been studied using the electron localization function and noncovalent reduced density gradient. The thermodynamic and nonlinear optical properties of methylurea crystalline hydrate have been determined. The atoms in molecules, electron localization functions, and localized orbital locator topological analyses have been carried out to elucidate the nature of hydrogen bonds in methylurea crystalline hydrates.

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Three-component condensation of α-nitroacetophenone, aromatic aldehydes, and methylurea

Cited by 3 publications

References 13 publications

Synthesis and Acylation of 4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)- ones

Synthesis and Acylation of 4-Chloroalkyl-3,4-dihydropyrimidin-2(1H)- ones

ChemInform Abstract: Three‐Component Condensation of α‐Nitroacetophenone, Aromatic Aldehydes, and Methylurea.

Noncovalent interactions in N-methylurea crystalline hydrates

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