Three-component hetero-domino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes to afford 1,3-dipropargylimidazolidines

Different intermediates are key molecules to synthesize high-added value bioactive and pharmacology molecules such as propargylamines may be synthesizedin several ways using catalysts in homogeneous and heterogeneous conditions. This review presents the catalysts which are used in the A3, AHA, and KA2 coupling reactions to afford propargylamines. It also provides a classification of all the propargylamines known up to date in the literature and their reported synthesis conditions.

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Three-component hetero-domino cyclization and copper-catalyzed double A3-coupling reaction of ethane-1,2-diamines, formaldehyde, and alkynes to afford 1,3-dipropargylimidazolidines

Cited by 3 publications

References 17 publications

Synthesis of N-substituted tetrapropargylamines by catalytic aminomethylation of α,ω-diacetylenes

Synthesis of N-substituted tetrapropargylamines by catalytic aminomethylation of α,ω-diacetylenes

Direct synthesis of N-substituted 1,3-oxazolidines via a hetero-domino Petasis borono-Mannich reaction of 1,2-amino alcohols, formaldehyde, and organoboronic acids

Catalysts For Propargylamines Synthesis Via A3, AHA, and KA2 Coupling - A Review

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