Three Component <i>syn</i>‐1,2‐Arylmethylation of Internal Alkynes**

Dutta, Shubham; Sahoo, Akhila K.

doi:10.1002/ange.202300610

Angewandte Chemie

2023

DOI: 10.1002/ange.202300610

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Three Component syn‐1,2‐Arylmethylation of Internal Alkynes**

Shubham Dutta

Akhila K. Sahoo

Abstract: A celebration of Prof. Sukh Dev's lifetime contribution to organic chemistry on his 100th birthday.

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2024

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Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones

Rajput,

Garg,

Jain

2024

Adv Synth Catal

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A photoinduced direct synthesis of 3‐amino‐1‐indenones via radical cascade cyclization strategy is demonstrated. The methodology involves a domino reaction between 2‐alkynylarylnitrile and N‐aminopyridinium salt and captures the reactivity of in‐situ generated nitrogen‐centered radical (NCR) in visible light. Multiple bond‐forming events including C‐N, C‐C, and C‐O take place sequentially on 2‐alkynylarylnitrile enabling construction of 3‐amino‐1‐indenone core at room temperature in 35‐76% yields. A preliminary biological screening of synthesized compounds is indicative of their potent anti‐cancer property.

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Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones

Rajput,

Garg,

Jain

2024

Adv Synth Catal

View full text Add to dashboard Cite

show abstract

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Three Component syn‐1,2‐Arylmethylation of Internal Alkynes**

Abstract: A celebration of Prof. Sukh Dev's lifetime contribution to organic chemistry on his 100th birthday.

Cited by 1 publication

References 64 publications

Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones

Photoredox Radical Cascade Cyclization of 2‐Alkynylarylnitriles in Visible Light: Direct Access to 3‐Amino‐1‐indenones

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