Three-component one-pot synthesis of new spiro[indoline-pyrrolidine] derivatives mediated by 1,3-dipolar reaction and DFT analysis

Engaging Isatins and Amino Acids in Multicomponent One-Pot 1,3-Dipolar Cycloaddition Reactions—Easy Access to Structural Diversity

“…The regio- and stereochemical outcomes of this cycloaddition reaction were determined through spectroscopic analysis. The geometries and electronic structures of the resulting compounds were further investigated using DFT quantum chemical calculations, aiming to establish a comprehensive understanding of the experimental results [ 69 ].…”

“…The regio-and stereochemical outcomes of this cycloaddition reaction were determined through spectroscopic analysis. The geometries and electronic structures of the resulting compounds were further investigated using DFT quantum chemical calculations, aiming to establish a comprehensive understanding of the experimental results [69]. In 2021, the Maniam group successfully demonstrated a microwave-assisted, onepot, three-component 1,3-dipolar cycloaddition of azomethine ylides derived from Lproline and isatin with various β-nitrostyrenes 16 (Scheme 4).…”

“…The regio-and stereochemical outcomes of this cycloaddition reaction were determined through spectroscopic analysis. The geometries and electronic structures of the resulting compounds were further investigated using DFT quantum chemical calculations, aiming to establish a comprehensive understanding of the experimental results [69]. In 2021, Quiroga et al achieved a one-pot sequential three-component synthesis of novel spiro[indoline-pyrrolidine] derivatives 13 using trans-1,2-dibenzoylethylene 12 as the dipolarophile (Scheme 3).…”