Three Component Synthesis of 4‐Aryl‐2‐aminothiazoles under Transition‐Metal Free Conditions

Abstract

An efficient three‐component synthesis of 4‐aryl‐2‐aminothiazoles was reported. Thus, phenyl‐thioureas reacted with 2‐bromoacetophenones to form 4‐aryl‐2‐aminothiazoles through cyclization, and the subsequent C‐N bonding with benzyl/allyl bromides gave the desired disubstituted thiazoles smoothly. The protocol features transition‐metal free, short reaction time, easily available starting materials, good yields and broad substrate scope, showing potential synthetic value for the synthesis of a variety of biologically or pharmaceutically active compounds.