Pilomatricoma is a relatively rare tumour of the skin. It derived from primitive basal cells of epidermis that differentiate into hair matrix cells. It usually arises from the lids and eyebrows. Tumour appear as solitary, firm nodules, exhibiting a normal to pearl white epidermis. A 25-year-old female in her third month of pregnancy, presented with an asymptomatic erythematous nodule 7 weeks. Examination revealed an erythematous nodule, measured approximately 1, 5 cm in diameter firm, with yellowish zones and dotted with telangiectasia. Dermoscopy demonstrated yellowish lobules surrounded by crown-like branching vessels. Patient underwent surgical excision. Microscopic examination revealed a pilomatricoma. After a follow-up of 10 months, the evolution was favorable without recurrence. We report the clinical, dermoscopic, therapeutic and evolutionary characteristics of a case of pilomatricoma in order to help clinicians to better diagnose this entity and decrease the rate of misdiagnosis, especially in pregnant women.