“…Besides, the proposed approach in our study could also realize the quantitative estimation and risk stratification for patients with LUSC and LUAD, promisingly working as an effective and complementary tool to help the clinicians make appropriate treatment decisions. Apart from the current study, development of the quantitative image-based diagnostic models for disease definition has received unprecedented attention these years [2,7,18,25,38,[43][44][45][46][47], not only in the field of cancer diseases, but also in more broad research fields, such as retinal diseases [43,44], diabetes [46], calcaneal fracture [45], and mental disorders [36]. These models have achieved favorable performance in diseases diagnoses and understanding, demonstrating the great power and promising application of these approaches for clinical practice.…”