Three-dimensional analysis for radio-frequency ablation of liver tumor with blood perfusion effect

Sheu, Tony W. H.; Chou, Chen-Kuan; Tsai, Susan; Liang, Po-Chin

doi:10.1080/10255840500289731

Cited by 21 publications

(17 citation statements)

References 14 publications

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“…However, this technique does not provoke an even heating of the target zone due to a heterogeneous distribution of the wave energy. During radiofrequency ablation, thermal energy is radiated from electrodes and propagates [111]. Heat radiation re-emitted from target organs is proportional to the square of the RF alternating current.…”

Section: Tissue Heating By Electromagnetic Wavesmentioning

confidence: 99%

Biofluid Flow and Heat Transfer

Thiriet¹,

Sheu²,

Garon³

2016

Handbook of Fluid Dynamics, Second Edition

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2nd EditionInternational audienceMajor moving biological fluids, or biofluids, are blood and air that cooperate to bring oxygento the body’s cells and eliminate carbon dioxide produced by these cells. Blood is conveyed ina closed network composed of 2 circuits in series — the systemic and pulmonary circulation—, each constituted by arteries, capillaries, and veins, under the synchronized action of theleft and right cardiac pumps, respectively. Air is successively inhaled from and exhaled to theatmosphere through the airway openings (nose and/or mouth). In the head, blood generatesthe cerebrospinal fluid in choroid plexi of all compartments of the ventricular system andreceives it in arachnoid villi. Other biofluids are either secreted, such as bile from the liverand breast milk that both transport released substances with specific tasks, or excreted,such as urine from kidneys or sweat from skin glands that both convey useless materials andwaste produced by the cell metabolism. In addition to the convective transport, peristalsis,which results from the radial contraction and relaxation of mural smooth muscles, propelsthe content of the lumen of the muscular bioconduit (e.g., digestive tract) in an anterogradedirection.Blood circulation and air flow in the respiratory tract are widely explored because oftheir vital functions. Note that inhaled air is transported through the respiratory tract bytwo processes: convection down to bronchioles and diffusion down to pulmonary alveoli.1Furthermore, investigations of these physiological flows in deformable bioconduits give riseto models such as the Starling resistance that themselves become object of new study fieldsin physics and mechanics (e.g., collapsible tubes) as well as of new developments in math-ematical modeling and scientific computing. Whereas fluid–structure interaction problemsin aeronautics and civil engineering deal with materials of distinct properties, blood streamand vessel wall correspond to two domains of nearly equal physical properties, as both bloodand vessels have densities close to that of water. New processing strategies must then beconceived

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Section: Tissue Heating By Electromagnetic Wavesmentioning

confidence: 99%

Biofluid Flow and Heat Transfer

Thiriet¹,

Sheu²,

Garon³

2016

Handbook of Fluid Dynamics, Second Edition

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“…To retain the prediction accuracy at a lower computational cost, we are motivated to develop a scheme that can give us the accuracy order of six in a grid stencil involving only three points. To achieve the above goal, we define firstly the spatial derivatives u (2) ≡ u xx , u (4) ≡ u xxxx and u (6) at a nodal point j as follows:…”

Section: Acoustic Streaming Hydrodynamic Equationsmentioning

confidence: 99%

“…Convective cooling protects tumor cells from thermal destruction [4,5] and, consequently, causes the recurrent cancer. Blood flow can carry away a large part of the deposited energy; therefore, more energy is necessary for the ablation of tumor close to blood vessel.…”

Section: Introductionmentioning

confidence: 99%

Image-based computational model for focused ultrasound ablation of liver tumor

Solovchuk

Sheu

Thiriet³

2014

J Comput Surg

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High-intensity focused ultrasound (HIFU) is a rapidly developing medical technology that allows non-invasive thermal ablation of tumors. Thermal treatment of liver tumor, which is one of the most common malignancies worldwide, is problematic because large blood vessels act as a heat sink. Convective cooling protects the cancer cells from thermal destruction and decreases the necrosed volume. A major objective of the method development is to achieve a virtually complete necrosis of tumors close to major blood vessels and to avoid blood vessel damage and, hence, the needed treatment planning. The present study is aimed at predicting liver tumor temperature during HIFU thermal ablation in a patient-specific liver geometry. The model comprises the nonlinear Westervelt equation and bioheat equations in the liver and blood vessels. The nonlinear hemodynamic equations are also taken into account with the convected cooling and acoustic streaming effects being taken into account. We found from this three-dimensional three-field coupling study that in large blood vessels, both convective cooling and acoustic streaming may change the temperature considerably near the blood vessel. More precisely, acoustic streaming velocity magnitude can be several times larger than the blood vessel velocity. The results presented in the current work can be further used to construct a surgical planning platform.

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“…They range from simple geometric models that use ellipsoids to describe the necrosis [11] over time dependent PDE models with constant coefficients [13,16] to complex models that take cell water evaporation and temperature dependent material parameters into account [14,15,17]. Some authors exploit rotational symmetry around the applicator axis [12], which is of course impossible if the aim is to consider patient individual vascular systems.…”

Section: 1)mentioning

confidence: 99%

“…The way in which vascular cooling is taken into account varies considerably: Simple models use heuristics to quantify the cooling effects [11] or do not consider patient individual vascular systems at all [12]. More advanced approaches model individual vessels by a fixed heat sink [13,14], and some authors even take blood flow together with heat exchange between vessel and tissue into account [15][16][17]. For a comprehensive review, see the overview article by Berjano [18].…”

Section: Introductionmentioning

confidence: 99%

Fast Estimation of the Vascular Cooling in RFA Based on Numerical Simulation

Kröger¹,

Pätz²,

Altrogge³

et al. 2010

TOBEJ

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Abstract:We present a novel technique to predict the outcome of an RF ablation, including the vascular cooling effect. The main idea is to separate the problem into a patient independent part, which has to be performed only once for every applicator model and generator setting, and a patient dependent part, which can be performed very fast. The patient independent part fills a look-up table of the cooling effects of blood vessels, depending on the vessel radius and the distance of the RF applicator from the vessel, using a numerical simulation of the ablation process. The patient dependent part, on the other hand, only consists of a number of table look-up processes. The paper presents this main idea, along with the required steps for its implementation. First results of the computation and the related ex-vivo evaluation are presented and discussed. The paper concludes with future extensions and improvements of the approach.

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Three-dimensional analysis for radio-frequency ablation of liver tumor with blood perfusion effect

Cited by 21 publications

References 14 publications

Biofluid Flow and Heat Transfer

Biofluid Flow and Heat Transfer

Image-based computational model for focused ultrasound ablation of liver tumor

Fast Estimation of the Vascular Cooling in RFA Based on Numerical Simulation

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