2018
DOI: 10.3389/fpls.2018.00057
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Three-Dimensional Architecture and Biogenesis of Membrane Structures Associated with Plant Virus Replication

Abstract: Positive-sense (+) RNA viruses represent the most abundant group of viruses and are dependent on the host cell machinery to replicate. One remarkable feature that occurs after (+) RNA virus entry into cells is the remodeling of host endomembranes, leading to the formation of viral replication factories. Recently, rapid progress in three-dimensional (3D) imaging technologies, such as electron tomography (ET) and focused ion beam-scanning electron microscopy (FIB-SEM), has enabled researchers to visualize the no… Show more

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Cited by 51 publications
(45 citation statements)
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References 178 publications
(244 reference statements)
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“…Since dsRNA is the intermediate for viral replication, these results thus confirmed the previous suggestion that robust replication occurs in X-bodies (6). The replication of many positive-stranded RNA viruses occurs in membranous inclusion bodies, vesicles, multivesicular bodies, or spherules that are remodeled from the plant cell endomembrane by viral protein(s) (45)(46)(47)(48). RdRp is the only viral protein that is absolutely required for PVX replication (3,4); however, a transmembrane domain or membrane-associated motif has not yet been revealed.…”
Section: Discussionsupporting
confidence: 86%
“…Since dsRNA is the intermediate for viral replication, these results thus confirmed the previous suggestion that robust replication occurs in X-bodies (6). The replication of many positive-stranded RNA viruses occurs in membranous inclusion bodies, vesicles, multivesicular bodies, or spherules that are remodeled from the plant cell endomembrane by viral protein(s) (45)(46)(47)(48). RdRp is the only viral protein that is absolutely required for PVX replication (3,4); however, a transmembrane domain or membrane-associated motif has not yet been revealed.…”
Section: Discussionsupporting
confidence: 86%
“…1b). The latter may appear likely given that plant viruses generally replicate their genomes in close association with endomembrane compartments (Jin et al, 2018;Laliberté and Sanfaçon, 2010;Verchot, 2011). In the case of the model plant virus Tobacco mosaic virus (TMV), for example, replication takes place in viral replication complexes embedded in modified ER (Heinlein et al, 1998;Reichel and Beachy, 1998).…”
Section: Endomembrane-associated Intracellular Perception Of Dsrnamentioning
confidence: 99%
“…Plant virus replication and movement are genetically determined by a combination of viral and host factors coordinated in a temporal and spatial manner [ 4 , 5 , 6 ]. Viruses express their genes through an RNA intermediate [ 7 ].…”
Section: Introductionmentioning
confidence: 99%