Three‐Dimensional Architecture of Genomes

Bottom–up modeling of chromatin segregation due to epigenetic modifications

“…The determination of the 3D organization of DNA from nucleosomes to the full chromosome remains a challenge. Interphase chromatin organization appears quite random (6), with cell-to-cell variability in relative loci positions (7). The most prominent nonrandom feature of chromatin organization is the physical connectivity of the DNA backbone itself, and physical models of chromatin must begin with this connectivity (8–21).…”