2006
DOI: 10.1002/adma.200600647
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Three‐Dimensional Biochemical and Biomechanical Patterning of Hydrogels for Guiding Cell Behavior

Abstract: The ability to tailor the biochemical and biomechanical properties of 3D materials at the microscale is important for a range of biotechnology applications, including the engineering of complex tissues, the development of biosensors, the elucidation of cell-cell and cell-material interactions, and the guidance of cellular differentiation. [1,2] To this end, techniques have emerged for the fabrication of 3D microcontrolled materials, including conventional photolithographic patterning, [3,4] electrochemical dep… Show more

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Cited by 395 publications
(337 citation statements)
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“…While early efforts generated patterns by UV exposure through a simple mask, 21 recent work has become far more elaborate. For instance, Hahn et al 16 showed that two-photon activation can generate three-dimensional patterns of acrylated PEG with microscale resolution throughout the bulk of the gel.…”
Section: Photopatterningmentioning
confidence: 99%
“…While early efforts generated patterns by UV exposure through a simple mask, 21 recent work has become far more elaborate. For instance, Hahn et al 16 showed that two-photon activation can generate three-dimensional patterns of acrylated PEG with microscale resolution throughout the bulk of the gel.…”
Section: Photopatterningmentioning
confidence: 99%
“…PEG has a well-established chemistry and long history of safety in vivo. Addition of acrylate groups flanking the PEG chain allows for photo or chemical cross-linking of a PEGDA macromer solution, as well as incorporation of biomolecules such as protease-degradable sites, adhesive ligands, and growth factors (14)(15)(16). A major strength of this strategy is the modular "plugand-play" design of the base hydrogel system, which allows the tailoring of the biochemical and mechanical properties of the delivery vehicle.…”
mentioning
confidence: 99%
“…Furthermore, hydrogels can also be structured photolithographically, taking advantage of diffusion processes. Three-dimensional structuring at the microscale results in the ability to spatially tailor biomechanical and biochemical material properties [52].…”
Section: Biomedicinementioning
confidence: 99%