Three-Dimensional Brain Metabolic Imaging in Patients with Toxic Encephalopathy

Callender, Thomas J.; Morrow, Lisa A.; Subramanian, K. S.; Duhon, Dan; Ristovv, Mona

doi:10.1016/b978-0-12-059785-7.50047-8

Cited by 20 publications

(23 citation statements)

References 23 publications

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“…In a previous study of SPECT brain scans of workers who developed clinical toxic encephalopathy after exposure to neurotoxins, SPECT was found to be more sensitive in detecting abnormalities than neuropsychological evaluations, nerve conduction velocity (NCV), current perceptions threshold (CPT) sensory nerve testing, vestibular function testing, olfactory testing, sleep encephalogram (EEG) analysis, EEG, TCT, or MRI [Callender et al, 1993]. SPECT imaging may contribute to the development of a biological marker of neurotoxicity.…”

Section: Introductionmentioning

confidence: 94%

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

et al. 1997

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Section: Introductionmentioning

confidence: 94%

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

et al. 1997

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“…Long-term exposure to low airborne exposure concentrations is likely to produce slight pre-narcotic or irritation symptoms such as headache, nausea, inappropriate laughing or angriness, dizziness, imbalance and eye irritation [12,17]. In addition, as for acute intoxications, chronic exposure conditions may lead to cortical and subcortical atrophy on CT-scan and di use diminished blood ow on Single Photon Emission Tomography (SPECT) examination [12,18].…”

mentioning

confidence: 99%

Effects of long-term low-level solvent exposure on cognitive function

Saygun

Ekici²,

Muluk³

et al. 2012

CIM

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TurkeyE ects of long-term low-level solvent exposure on cognitive function Abstract Purpose: e e ects of long-term low-level exposures to solvents on cognitive function were investigated.Methods: A total of 389 workers at a gun factory, those exposed to solvents (n=193) and those that were not exposed to solvents during work (n=196), were included. All the workers were given a questionnaire. Cognitive function was evaluated by Mini-mental Status Examination (MMSE) and psychological status was assessed by Hospital Anxiety and Depression (HAD) Scale. Results:No di erences were found in the MMSE and HAD scores between solventexposed workers and control workers (p>0.05). In the workers who had used a mask for a longer time, orientation scores were lower. Daytime sleepiness was related to lower recall scores.. Le -handed workers had higher total HAD scores than right-handed workers.Conclusions: Long-term low-level exposure to solvents did not a ect cognitive function in the workers, according to their MMSE scores. Duration of solvent exposure was also not related to MMSE Scores. Short sleep duration and daytime sleepiness may negatively a ect cognitive function.

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“…Die Hemmung der Cytochromoxidase-Aktivität ist auch eine mög-liche Erklärung für die Schwefelwasserstoff-induzierte Schädigung des olfaktorischen Epithels bei Ratten und Mäusen (Dorman et al 2004). In Einzelfallstudien, die mit bildgebenden Verfahren (SPECT, PET) funktionelle Veränderungen im ZNS bei chronisch (Callender et al 1993) und akut (Schneider et al 1998) gegenüber Schwefelwasserstoff exponierten Arbeitern untersuchen, wird die Hemmung der Cytochromoxidase-Aktivität als mögliche Ursache für die beobachtete Hypoperfusion in den Basalganglien (Putamen) diskutiert. Vor allem in der akuten Studie zeigt der untersuchte Patient Defizite in neuropsychologischen Testleistungen (z.…”

Section: Wirkungsmechanismusunclassified

Schwefelwasserstoff [MAK Value Documentation in German language, 2007]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 43. Lieferung, Ausgabe 2007 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Aufnahme, Verteilung, Ausscheidung Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Three-Dimensional Brain Metabolic Imaging in Patients with Toxic Encephalopathy

Cited by 20 publications

References 23 publications

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

Comparison of single photon emission computed tomography findings in cases of healthy adults and solvent-exposed adults

Effects of long-term low-level solvent exposure on cognitive function

Schwefelwasserstoff [MAK Value Documentation in German language, 2007]

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