Three-dimensional chitin rings from body segments of a pet diplopod species: Characterization and protein interaction studies

Kaya, Murat; Mulerčikas, Povilas; Sargın, İdris; Kazlauskaitė, Sonata; Baublys, Vykintas; Akyuz, Bahar; Bulut, Esra; Tubelytė, Vaida

doi:10.1016/j.msec.2016.06.046

Cited by 11 publications

(10 citation statements)

References 51 publications

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“…In addition, after chitin adsorbed RBG 6B on surface it has still heterogeneous surface. As reported in the literature, chitins gained from several organisms exhibit similar surface morphologies (Cárdenas et al, 2004;Erdogan and Kaya, 2016;Kaya et al, 2016;Waśko et al, 2016). As seen in Fig 4 (a-b), the elemental analysis of the chitin is shown that C, N and O are main constituents of the chitin, and after dyed by RBG 6B, C percentage of chitin increased.…”

Section: Characterization Of Chitinsupporting

confidence: 73%

Adsorption of Remazol Brillant Green 6B (RBG 6B) on chitin: process optimization using response surface methodology

2018

Global NEST Journal

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In the present study, the adsorption of Remazol Brillant Green 6B (RBG 6B) on chitin which characterized by BET, FTIR, XRD and SEM analysis was studied. Response surface methodology (RSM) was applied to determine interaction between solution pH, initial RBG 6B concentration and chitin dosage being individual variables and to optimize operating conditions. According to results of variance analysis (ANOVA), the second order polynomial model was statistically significant (P<0.0001) and coefficient of determination value (R2=0.98) was high. It was determined that dye removal efficiency increased when low solution pH and initial RBG 6B dye concentration and high chitin dosage were used. The maximum dye removal efficiency was obtained as 88% at solution pH of 3.0, initial RBG 6B concentration of 75 mg L-1 and chitin dosage of 5.0 g L-1. The isotherms and kinetics studies showed that Freundlich isotherm and pseudo-second-order kinetics model fitted well to the RBG 6B adsorption data.

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Section: Characterization Of Chitinsupporting

confidence: 73%

Adsorption of Remazol Brillant Green 6B (RBG 6B) on chitin: process optimization using response surface methodology

2018

Global NEST Journal

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“…60 Notably, as bioconvertersreared for organic waste management and animal feed productioninsects can be exploited as a valid alternative to crustaceans as a source for chitin and chitosan for greater ecological and economic sustainability. 61 Arthropods, including centipedes 62,63 and woodlice, 64,65 have been investigated as sources of chitin. Notably, the body segments of large centipedes are suitable for the production of three-dimensional chitin rings.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, the body segments of large centipedes are suitable for the production of three-dimensional chitin rings. 62 In addition, chitin has been extracted from poriferans, 66 bryozoans 67 and tardigrades 68 and from guano of insectivorous bats. 69 Quo vadis insect chitin?…”

Section: Introductionmentioning

confidence: 99%

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Current state of chitin purification and chitosan production from insects

Hahn

Tafi

Paul

et al. 2020

J of Chemical Tech & Biotech

231

113

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Chitin, and especially its deacetylated variant chitosan, has many applications, e.g. as carrier material for pharmaceutical drugs or as a flocculant in wastewater treatment. Despite its versatility and accessibility, chitin, the second most abundant polysaccharide on Earth, has so far been commercially extracted only from crustaceans and to a minor extent from fungi. Insects are a viable alternative source of chitin, but they have not been exploited in the past due to limited availability. Today however, for the sustainable production of animal feed, insect farming is being developed substantially. The availability of large quantities of insect biomass and chitin-rich side products such as exuviae and exoskeletons has been increasing. This review provides an overview of recently published studies of chitin extraction from insects, its subsequent conversion into chitosan and the primary analytical methods used to characterize insect-based chitin and chitosan. We have discovered a large number of research articles published over the past 20 years, confirming the increased attention being received by chitin and chitosan production from insects. Despite numerous publications, we identified several knowledge gaps, such as a lack of data concerning chitin purification degree and chitosan yield. Furthermore, analytical methods used to obtain physicochemical characteristics, structural information and chemical composition meet basic qualitative requirements but do not satisfy the need for a more quantitative evaluation. Despite the current shortcomings that need to be overcome, this review presents encouraging data on the use of insects as an alternative source of chitin and chitosan in the future.

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“…Recently, BSA has been commonly used as a suitable carrier and stabilizer for drug delivery systems due to its superior advantages, such as a lack of immunogenicity, toxicity, and good biodegradability. [25][26][27] In addition, BSA exhibits easy accumulation and good uptake in inflamed tissues, 28 and it has been investigated in various drug delivery systems, such as nanoparticles, 29,30 microspheres, 31,32 conjugates, 33,34 and nanosuspensions. 35 Currently, BSA is widely used as an excellent stabilizer instead of other organic stabilizers with potential toxicity, such as sodium dodecyl sulfate (SDS), Poloxamer 188, and Poloxamer 407.…”

Section: Introductionmentioning

confidence: 99%

A novel albumin wrapped nanosuspension of meloxicam to improve inflammation-targeting effects

Chen

Liu

et al. 2018

IJN

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BackgroundThe objective of this study was to develop a more bio-available and safe nanosuspension of meloxicam (MX), which could dramatically improve inflammation targeting.Methods and resultsMX-loaded bovine serum albumin (BSA) nanosuspensions were prepared using acid–base neutralization in aqueous solution and the prepared nanosuspensions were characterized. The results obtained showed that the prepared nanosuspensions had a narrow size distribution with a mean particle size of 78.67±0.22 nm, a polydispersity index of 0.133±0.01, and a zeta potential of −11.87±0.91 mV. The prepared MX nanosuspensions were spherically wrapped by BSA with a smooth surface as shown by transmission electron microscopy. Stability studies showed that the nanosuspensions were physically stable at 4°C with a shelf life of at least 6 months. In the in vitro dissolution test, the MX-loaded BSA nanosuspension (MX-BSA-NS) exhibited sustained release. In addition, an in vivo pharmacokinetic study in rats following intravenous injection showed that the half-life (t1/2), mean residence time (MRT), and area under the concentration–time curve (AUC0–∞) of MX-BSA-NS was increased by 169.83%, 150.13%, and 148.80%, respectively, in comparison with MX conventional solution (MX solution). Furthermore, results from inflammation targeting studies showed that the concentration of MX increased significantly in inflamed tissues but was reduced in normal tissues compared with the MX solution group after injection of MX-BSA-NS.ConclusionThe prepared MX-BSA-NS significantly increased the inflammation-targeting properties and bioavailability of MX, suggesting its potential as a promising formulation for the targeted drug delivery of MX in future clinical applications.

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Three-dimensional chitin rings from body segments of a pet diplopod species: Characterization and protein interaction studies

Cited by 11 publications

References 51 publications

Adsorption of Remazol Brillant Green 6B (RBG 6B) on chitin: process optimization using response surface methodology

Adsorption of Remazol Brillant Green 6B (RBG 6B) on chitin: process optimization using response surface methodology

Current state of chitin purification and chitosan production from insects

A novel albumin wrapped nanosuspension of meloxicam to improve inflammation-targeting effects

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