Three-dimensional computer reconstruction of prostate cancer from radical prostatectomy specimens: evaluation of the model by core biopsy simulation

Egevad, Lars; Frimmel, Hans; Norberg, M.; Mattson, S.; Carlbom, Ingrid; Bengtsson, Ewert; Busch, Christer

doi:10.1016/s0090-4295(98)00425-7

Cited by 30 publications

(13 citation statements)

References 15 publications

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“…Another advancement has been to retrospectively analyse the biopsy process by means of three-dimensional computer simulation to determine the optimal combination and localisation of systematic biopsies for cancer detection [77][78][79].…”

Section: Discussion Of Overall Practice and Future Prospectsmentioning

confidence: 99%

A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer

et al. 2006

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Transrectal ultrasound (TRUS) is an important tool for urologists and radiologists in the detection of prostate cancer. Various TRUS-guided biopsy techniques are applied in clinical practice. Frequently, only the detection rates achieved with these methods are compared. Other diagnostic performance parameters, particularly the specificity and negative predictive value, are seldom compared. After extensive assessment of the available literature, this review describes the methods of TRUS-guided biopsy for prostate cancer detection. A distinction was made between systematic biopsies and biopsies that target a perceived (hypoechoic or Doppler-enhancing) lesion on imaging. Subsequently, the diagnostic performance (sensitivity, specificity, positive and negative predictive values, accuracies) was compared between these techniques. Imaging-guided biopsy showed better diagnostic performance than systematic biopsy with higher sensitivity. The combinations of sensitivity and specificity were highest for colour Doppler and contrast-enhanced targeted biopsy. Studies targeting hypoechoic lesions had relatively high sensitivity, but specificity was low. Presently however, with widespread prostate-specific antigen screening, fewer prostate cancers are hypoechoic, and the value of targeting hypoechoic lesions has diminished. Performing colour or contrast-enhanced Doppler biopsy or adding these techniques to systematic biopsies improves diagnostic performance, particularly by increasing sensitivity.

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Section: Discussion Of Overall Practice and Future Prospectsmentioning

confidence: 99%

A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer

et al. 2006

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“…Further support for the importance of laterally directed biopsies comes from Egevad et al [11], who used data from radical prostatectomy specimens to reconstruct the localization of the tumors within the prostate and the performed computer–assisted core biopsy simulations. 16 of 16 cancers not detected by the standard sextant protocol were detected by the laterally directed pair of biopsies.…”

Section: Discussionmentioning

confidence: 99%

“…Our lateral biopsies were taken much more laterally and may well have included the inferior anterior horn, one of the target areas for extra biopsies according to their computer simulations. Even if based on reconstruction of radical prostatectomy specimens, these computer simulations have limitations illustrated by the fact that only 153 of 180 (85%) of the cancers in the series by Chen et al [12]were detected by their 10–core simulation and 67 of 81 (83%) in the series from Egevad et al [11]using their 10–core protocol.…”

Section: Discussionmentioning

confidence: 99%

Outcome of Laterally Directed Sextant Biopsies of the Prostate in Screened Males Aged 50–66 Years

Aus¹,

Bergdahl²,

Hugosson³

et al. 2001

European Urology

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“…Various methods have been proposed to align histology slices, the most common is manual registration using interactive operator alignment 8,[19][20][21] . It is a laborious and time-consuming method, subject to inter-and intra-operator variability.…”

Section: Introductionmentioning

confidence: 99%

Robust alignment of prostate histology slices with quantified accuracy

et al. 2012

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Prostate cancer is the most common malignancy among men yet no current imaging technique is capable of detecting the tumours with precision. To evaluate each technique, the histology data must be precisely mapped to the imaged data. As it cannot be assumed that the histology slices are cut along the same plane as the imaged data is acquired, the registration is a 3D problem. This requires the prior accurate alignment of the histology slices. We propose a protocol to create in a rapid and standardised manner internal fiducial markers in fresh prostate specimens and an algorithm by which these markers can then be automatically detected and classified enabling the automatic rigid alignment of each slice. The protocol and algorithm were tested on 10 prostate specimens, with 19.2 histology slices on average per specimen. On average 90.9% of the fiducial markers created were visible in the slices, of which 96.1% were automatically correctly detected and classified. The average accuracy of the alignment was 0.19 ± 0.15 mm at the fiducial markers. The algorithm took 5.46 min on average per specimen. The proposed protocol and algorithm were also tested using simulated images and a beef liver sample. The simulated images showed that the algorithm has no associated residual error and justified the choice of a rigid registration. In the beef liver images, the average accuracy of the alignment was 0.11 ± 0.09 mm at the fiducial markers and 0.63 ± 0.47 mm at a validation marker approximately 20 mm from the fiducial markers.

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Three-dimensional computer reconstruction of prostate cancer from radical prostatectomy specimens: evaluation of the model by core biopsy simulation

Cited by 30 publications

References 15 publications

A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer

A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer

Outcome of Laterally Directed Sextant Biopsies of the Prostate in Screened Males Aged 50–66 Years

Robust alignment of prostate histology slices with quantified accuracy

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Three-dimensional computer reconstruction of prostate cancer from radical prostatectomy specimens: evaluation of the model by core biopsy simulation

Cited by 30 publications

References 15 publications

A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer

A comparison of the diagnostic performance of systematic versus ultrasound-guided biopsies of prostate cancer

Outcome of Laterally Directed Sextant Biopsies of the Prostate in Screened Males Aged 50&ndash;66 Years

Robust alignment of prostate histology slices with quantified accuracy

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Outcome of Laterally Directed Sextant Biopsies of the Prostate in Screened Males Aged 50–66 Years